Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/32163
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    Title: Long-term mortality of acetaminophen poisoning: a nationwide population-based cohort study with 10-year follow-up in Taiwan
    Authors: Huang, Hung-Sheng
    Ho, Chung-Han
    Weng, Shih-Feng
    Hsu, Chien-Chin
    Wang, Jhi-Joung
    Su, Shih-Bin
    Lin, Hung-Jung
    Huang, Chien-Cheng
    Contributors: Chi Mei Med Ctr, Dept Emergency Med
    Chi Mei Med Ctr, Dept Occupat Med
    Chi Mei Med Ctr, Dept Med Res
    Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
    Kaohsiung Med Univ, Dept Healthcare Adm & Med Informat
    Southern Taiwan Univ Sci & Technol, Dept Biotechnol
    Southern Taiwan Univ Sci & Technol, Dept Leisure Recreat & Tourism Management
    Chi Mei Med Ctr, Dept Med Res
    Taipei Med Univ, Dept Emergency Med
    Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth
    Southern Taiwan Univ Sci & Technol, Bachelor Program Senior Serv
    Chi Mei Med Ctr, Dept Geriatr & Gerontol
    Keywords: Acetaminophen
    Date: 2018-01-08
    Issue Date: 2019-11-15 15:43:20 (UTC+8)
    Abstract: Background: The long-term mortality of acetaminophen (APAP) poisoning has not yet been well studied; hence, we conducted this study to gain understanding of this issue. Methods: We conducted a nationwide population-based cohort study by identifying 3235 participants with APAP poisoning and 9705 participants without APAP poisoning in Taiwan between 2003 and 2012 in the Nationwide Poisoning Database and Longitudinal Health Insurance Database 2000. Participants with APAP poisoning and control subjects were compared for the risk of all-cause mortality by follow-up until 2013. Results: Two hundred forty-one participants with APAP poisoning (7.5%) and ninety-four control subjects (1.0%) died during the follow-up. Participants with APAP poisoning had a higher risk of all-cause mortality than the control subjects (incidence rate ratio [IRR], 8.1; 95% confidence interval [CI], 6.3-10.2), especially in the subgroup aged 20 years and younger (IRR, 27.3; 95% CI, 3.5-215.5) and in the first 12 months after poisoning (IRR, 16.0; 95% CI, 9.9-25.7). The increased risk of all-cause mortality was found even up to 2 years after the index poisoning. Conclusion: APAP poisoning was associated with increased long-term mortality. Early referral for intensive aftercare and associated interventions are suggested; however, further studies of the method are needed for clarification.
    Relation: Journal of Experimental & Clinical Cancer Research, v.26, 5
    Appears in Collections:[Dept. of Hospital and Health (including master's program)] Periodical Articles

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