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| 標題: | The prognostic value of N-terminal proB-type natriuretic peptide in patients with acute respiratory distress syndrome |
| 作者: | Lai, Chih-Cheng
Sung, Mei-I.
Ho, Chung-Han
Liu, Hsiao-Hua
Chen, Chin-Ming
Chiang, Shyh-Ren
Chao, Chien-Ming
Liu, Wei-Lun
Hsing, Shu-Chen
Cheng, Kuo-Chen |
| 貢獻者: | Chi Mei Med Ctr, Dept Intens Care Med
Chi Mei Med Ctr, Dept Internal Med
Chi Mei Med Ctr, Dept Med Res
Chia Nan Univ Pharm & Sci
Chi Mei Med Ctr, Dept Intens Care Med
Chung Hwa Univ Med Technol, Dept Safety Hlth & Environm Engn |
| 關鍵字: | Berlin Definition
Heart-Failure
Lung Injury
Brain
Outcomes
Severity
Utility
Ards |
| 日期: | 2017-03-21 |
| 上傳時間: | 2018-11-30 15:56:32 (UTC+8) |
| 出版者: | Nature Publishing Group |
| 摘要: | We investigated whether N-terminal proB-type natriuretic peptide (NT-proBNP) predicts the prognosis of patients with acute respiratory distress syndrome (ARDS). Between December 1, 2012, and May 31, 2015, this observational study recruited patients admitted to our tertiary medical center who met the Berlin criteria for ARDS and who had their NT-proBNP measured. The main outcome was 28-day mortality. We enrolled 61 patients who met the Berlin criteria for ARDS: 7 were classified as mild, 29 as moderate, and 25 as severe. The median APACHE II scores were 23 (interquartile range [IQR], 18-28), and SOFA scores were 11 (IQR, 8-13). The median lung injury score was 3.0 (IQR, 2.50-3.25), and the median level of NT-proBNP was 2011 pg/ml (IQR, 579-7216). Thirty-four patients died during this study, and the 28-day mortality rate was 55.7%. Patients who die were older and had significantly (all p < 0.05) higher APACHE II scores and NT-proBNP levels than did patients who survived. Multivariate analysis identified age (HR: 1.546, 95% CI: 1.174-2.035, p = 0.0019) and NT-proBNP (HR: 1.009, 95% CI: 1.004-1.013, p = 0.0001) as significant risk factors of death. NT-proBNP was associated with poor outcomes for patients with ARDS, and its level predicted mortality. |
| 關聯: | Scientific Reports, v.7, pp.44784 |
| 顯示於類別: | [醫務管理系(所)] 期刊論文
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