The prognostic value of N-terminal proB-type natriuretic peptide in patients with acute respiratory distress syndrome

doi:10.1038/srep44784

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Title:	The prognostic value of N-terminal proB-type natriuretic peptide in patients with acute respiratory distress syndrome
Authors:	Lai, Chih-Cheng Sung, Mei-I. Ho, Chung-Han Liu, Hsiao-Hua Chen, Chin-Ming Chiang, Shyh-Ren Chao, Chien-Ming Liu, Wei-Lun Hsing, Shu-Chen Cheng, Kuo-Chen
Contributors:	Chi Mei Med Ctr, Dept Intens Care Med Chi Mei Med Ctr, Dept Internal Med Chi Mei Med Ctr, Dept Med Res Chia Nan Univ Pharm & Sci Chi Mei Med Ctr, Dept Intens Care Med Chung Hwa Univ Med Technol, Dept Safety Hlth & Environm Engn
Keywords:	Berlin Definition Heart-Failure Lung Injury Brain Outcomes Severity Utility Ards
Date:	2017-03-21
Issue Date:	2018-11-30 15:56:32 (UTC+8)
Publisher:	Nature Publishing Group
Abstract:	We investigated whether N-terminal proB-type natriuretic peptide (NT-proBNP) predicts the prognosis of patients with acute respiratory distress syndrome (ARDS). Between December 1, 2012, and May 31, 2015, this observational study recruited patients admitted to our tertiary medical center who met the Berlin criteria for ARDS and who had their NT-proBNP measured. The main outcome was 28-day mortality. We enrolled 61 patients who met the Berlin criteria for ARDS: 7 were classified as mild, 29 as moderate, and 25 as severe. The median APACHE II scores were 23 (interquartile range [IQR], 18-28), and SOFA scores were 11 (IQR, 8-13). The median lung injury score was 3.0 (IQR, 2.50-3.25), and the median level of NT-proBNP was 2011 pg/ml (IQR, 579-7216). Thirty-four patients died during this study, and the 28-day mortality rate was 55.7%. Patients who die were older and had significantly (all p < 0.05) higher APACHE II scores and NT-proBNP levels than did patients who survived. Multivariate analysis identified age (HR: 1.546, 95% CI: 1.174-2.035, p = 0.0019) and NT-proBNP (HR: 1.009, 95% CI: 1.004-1.013, p = 0.0001) as significant risk factors of death. NT-proBNP was associated with poor outcomes for patients with ARDS, and its level predicted mortality.
Relation:	Scientific Reports, v.7, pp.44784
Appears in Collections:	[Dept. of Hospital and Health (including master's program)] Periodical Articles

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