End stage renal disease is associated with development of dementia

doi:10.18632/oncotarget.22458

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標題:	End stage renal disease is associated with development of dementia
作者:	Hung, Peir-Haur Yeh, Chih-Ching Hsiao, Chih-Yen Sung, Pi-Shan Muo, Chih-Hsin Sung, Fung-Chang Hung, Kuan-Yu Tsai, Kuen-Jer
貢獻者:	Ditmanson Med FdnChiayi Christian Hosp, Dept Internal Med Chia Nan Univ Pharm & Sci, Dept Appl Life Sci & Hlth Taipei Med Univ, Coll Publ Hlth & Nutr, Sch Publ Hlth China Med Univ, Dept Publ Hlth Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm Natl Cheng Kung Univ, Coll Med, Inst Clin Med Natl Cheng Kung Univ Hosp, Dept Neurol China Med Univ Hosp, Management Off Hlth Data China Med Univ, Coll Med, Sch Med, Grad Inst Clin Med Sci Natl Taiwan Univ Hosp, Hsinchu Branch, Dept Internal Med Natl Cheng Kung Univ, Coll Med,Natl Cheng Kung Univ Hosp, Ctr Clin Med
關鍵字:	Alzheimer's disease end stage renal disease hemodialysis peritoneal dialysis dementia Gerotarget
日期:	2017-12-08
上傳時間:	2018-11-30 15:55:13 (UTC+8)
出版者:	Impact Journals Llc
摘要:	There is controversy regarding the extent of risk for dementia in patients with end stage renal disease (ESRD) who are undergoing hemodialysis (HD) or peritoneal dialysis (PD). We examined data from Taiwan's Longitudinal Health Insurance Database, and used Cox proportional hazard regression analysis to compare the development of dementia in 72,934 HD and PD patients with 72,934 matched controls from January 1, 1999 to December 31, 2010. The results indicate an increased risk for dementia overall in HD patients (adjusted hazard ratio [aHR] = 1.64, p < 0.0001) and PD patients (aHR = 2.21, p < 0.0001). HD and PD patients also had significantly greater aHRs for vascular dementia (VaD) and unspecified dementia (UnD), but only HD patients had a significantly greater aHR for Alzheimer's disease (AD). Further research is needed to confirm whether management of ESRD with PD can reduce the incidence of AD, and to identify the mechanisms by which ESRD increases the risk of dementia.
關聯:	Oncotarget, v.8, n.64, pp.107348-107355
顯示於類別:	[醫務管理系(所)] 期刊論文 [生活保健科技系] 期刊論文

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