End stage renal disease is associated with development of dementia

doi:10.18632/oncotarget.22458

CNU IR > College of Smart Living > Dept. of Life and Health Science > Periodical Articles > Item 310902800/31748

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/31748

Title:	End stage renal disease is associated with development of dementia
Authors:	Hung, Peir-Haur Yeh, Chih-Ching Hsiao, Chih-Yen Sung, Pi-Shan Muo, Chih-Hsin Sung, Fung-Chang Hung, Kuan-Yu Tsai, Kuen-Jer
Contributors:	Ditmanson Med FdnChiayi Christian Hosp, Dept Internal Med Chia Nan Univ Pharm & Sci, Dept Appl Life Sci & Hlth Taipei Med Univ, Coll Publ Hlth & Nutr, Sch Publ Hlth China Med Univ, Dept Publ Hlth Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm Natl Cheng Kung Univ, Coll Med, Inst Clin Med Natl Cheng Kung Univ Hosp, Dept Neurol China Med Univ Hosp, Management Off Hlth Data China Med Univ, Coll Med, Sch Med, Grad Inst Clin Med Sci Natl Taiwan Univ Hosp, Hsinchu Branch, Dept Internal Med Natl Cheng Kung Univ, Coll Med,Natl Cheng Kung Univ Hosp, Ctr Clin Med
Keywords:	Alzheimer's disease end stage renal disease hemodialysis peritoneal dialysis dementia Gerotarget
Date:	2017-12-08
Issue Date:	2018-11-30 15:55:13 (UTC+8)
Publisher:	Impact Journals Llc
Abstract:	There is controversy regarding the extent of risk for dementia in patients with end stage renal disease (ESRD) who are undergoing hemodialysis (HD) or peritoneal dialysis (PD). We examined data from Taiwan's Longitudinal Health Insurance Database, and used Cox proportional hazard regression analysis to compare the development of dementia in 72,934 HD and PD patients with 72,934 matched controls from January 1, 1999 to December 31, 2010. The results indicate an increased risk for dementia overall in HD patients (adjusted hazard ratio [aHR] = 1.64, p < 0.0001) and PD patients (aHR = 2.21, p < 0.0001). HD and PD patients also had significantly greater aHRs for vascular dementia (VaD) and unspecified dementia (UnD), but only HD patients had a significantly greater aHR for Alzheimer's disease (AD). Further research is needed to confirm whether management of ESRD with PD can reduce the incidence of AD, and to identify the mechanisms by which ESRD increases the risk of dementia.
Relation:	Oncotarget, v.8, n.64, pp.107348-107355
Appears in Collections:	[Dept. of Hospital and Health (including master's program)] Periodical Articles [Dept. of Life and Health Science] Periodical Articles

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