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請使用永久網址來引用或連結此文件:
https://ir.cnu.edu.tw/handle/310902800/31748
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| 標題: | End stage renal disease is associated with development of dementia |
| 作者: | Hung, Peir-Haur
Yeh, Chih-Ching
Hsiao, Chih-Yen
Sung, Pi-Shan
Muo, Chih-Hsin
Sung, Fung-Chang
Hung, Kuan-Yu
Tsai, Kuen-Jer |
| 貢獻者: | Ditmanson Med FdnChiayi Christian Hosp, Dept Internal Med
Chia Nan Univ Pharm & Sci, Dept Appl Life Sci & Hlth
Taipei Med Univ, Coll Publ Hlth & Nutr, Sch Publ Hlth
China Med Univ, Dept Publ Hlth
Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
Natl Cheng Kung Univ, Coll Med, Inst Clin Med
Natl Cheng Kung Univ Hosp, Dept Neurol
China Med Univ Hosp, Management Off Hlth Data
China Med Univ, Coll Med, Sch Med, Grad Inst Clin Med Sci
Natl Taiwan Univ Hosp, Hsinchu Branch, Dept Internal Med
Natl Cheng Kung Univ, Coll Med,Natl Cheng Kung Univ Hosp, Ctr Clin Med |
| 關鍵字: | Alzheimer's disease
end stage renal disease
hemodialysis
peritoneal dialysis
dementia
Gerotarget |
| 日期: | 2017-12-08 |
| 上傳時間: | 2018-11-30 15:55:13 (UTC+8) |
| 出版者: | Impact Journals Llc |
| 摘要: | There is controversy regarding the extent of risk for dementia in patients with end stage renal disease (ESRD) who are undergoing hemodialysis (HD) or peritoneal dialysis (PD). We examined data from Taiwan's Longitudinal Health Insurance Database, and used Cox proportional hazard regression analysis to compare the development of dementia in 72,934 HD and PD patients with 72,934 matched controls from January 1, 1999 to December 31, 2010. The results indicate an increased risk for dementia overall in HD patients (adjusted hazard ratio [aHR] = 1.64, p < 0.0001) and PD patients (aHR = 2.21, p < 0.0001). HD and PD patients also had significantly greater aHRs for vascular dementia (VaD) and unspecified dementia (UnD), but only HD patients had a significantly greater aHR for Alzheimer's disease (AD). Further research is needed to confirm whether management of ESRD with PD can reduce the incidence of AD, and to identify the mechanisms by which ESRD increases the risk of dementia. |
| 關聯: | Oncotarget, v.8, n.64, pp.107348-107355 |
| 顯示於類別: | [醫務管理系(所)] 期刊論文
[生活保健科技系] 期刊論文
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