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| 標題: | 2-Adamantanamine produces prolonged spinal block in rats |
| 作者: | Chen, Yu-Wen
Chen, Chia-Ming
Liu, Kuo-Sheng
Wang, Jhi-Joung
Hung, Ching-Hsia |
| 貢獻者: | Chi Mei Med Ctr, Dept Med Res
China Med Univ, Dept Phys Therapy, Coll Hlth Care
China Med Univ, Grad Inst Rehabil Sci, Coll Hlth Care
Chi Mei Med Ctr, Dept Anesthesiol
Chia Nan Univ Pharm & Sci, Dept Pharm
Natl Cheng Kung Univ, Dept Phys Therapy, Coll Med
Natl Cheng Kung Univ, Coll Med, Inst Allied Hlth Sci |
| 關鍵字: | Intrathecal injection
2-adamantanamine
Mepivacairie
Nociception
Proprioception
Motor function |
| 日期: | 2017-06-13 |
| 上傳時間: | 2018-11-30 15:54:48 (UTC+8) |
| 出版者: | Elsevier Ireland Ltd |
| 摘要: | We aimed to investigate the local anesthetic effect of 2-adamantanamine in spinal anesthesia. The dose-response curves were constructed after intrathecally injecting the rats with five doses of 2-adamantanamine and a common local anesthetic mepivacaine. The quality and duration of 2-adamantanamine at producing spinal nociceptive, proprioceptive and motor block were compared with that of mepivacaine. We revealed that 2-adamantanamine provoked spinal nociceptive, proprioceptive and motor block dose-dependently. On the 50% effective dose (ED50) basis, the rank of potency was mepivacaine > 2-adamantanamine at producing spinal nociceptive, proprioceptive and motor block (p < 0.05 for the differences). 2-Adamantanamine, but not mepivacaine produced more nociceptive block than motor block (p < 0.05). At the equianesthetic doses (ED75, ED50, and ED25), the nociceptive block duration caused by 2-adamantanamine was greater than that caused by mepivacaine (p < 0.01 for the differences). These preclinical data showed that 2-adamantanamine is less potent than mepivacaine, while 2-adamantanamine provokes greater duration of spinal nociceptive block than mepivacaine. Furthermore, 2-adamantanamine demonstrates a more nociceptive-selective action over motor block. (C) 2017 Elsevier B.V. All rights reserved. |
| 關聯: | Neuroscience Letters, v.653, pp.168-172 |
| 顯示於類別: | [藥學系(所)] 期刊論文
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