2-Adamantanamine produces prolonged spinal block in rats

doi:10.1016/j.neulet.2017.05.043

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Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/31737

Title:	2-Adamantanamine produces prolonged spinal block in rats
Authors:	Chen, Yu-Wen Chen, Chia-Ming Liu, Kuo-Sheng Wang, Jhi-Joung Hung, Ching-Hsia
Contributors:	Chi Mei Med Ctr, Dept Med Res China Med Univ, Dept Phys Therapy, Coll Hlth Care China Med Univ, Grad Inst Rehabil Sci, Coll Hlth Care Chi Mei Med Ctr, Dept Anesthesiol Chia Nan Univ Pharm & Sci, Dept Pharm Natl Cheng Kung Univ, Dept Phys Therapy, Coll Med Natl Cheng Kung Univ, Coll Med, Inst Allied Hlth Sci
Keywords:	Intrathecal injection 2-adamantanamine Mepivacairie Nociception Proprioception Motor function
Date:	2017-06-13
Issue Date:	2018-11-30 15:54:48 (UTC+8)
Publisher:	Elsevier Ireland Ltd
Abstract:	We aimed to investigate the local anesthetic effect of 2-adamantanamine in spinal anesthesia. The dose-response curves were constructed after intrathecally injecting the rats with five doses of 2-adamantanamine and a common local anesthetic mepivacaine. The quality and duration of 2-adamantanamine at producing spinal nociceptive, proprioceptive and motor block were compared with that of mepivacaine. We revealed that 2-adamantanamine provoked spinal nociceptive, proprioceptive and motor block dose-dependently. On the 50% effective dose (ED50) basis, the rank of potency was mepivacaine > 2-adamantanamine at producing spinal nociceptive, proprioceptive and motor block (p < 0.05 for the differences). 2-Adamantanamine, but not mepivacaine produced more nociceptive block than motor block (p < 0.05). At the equianesthetic doses (ED75, ED50, and ED25), the nociceptive block duration caused by 2-adamantanamine was greater than that caused by mepivacaine (p < 0.01 for the differences). These preclinical data showed that 2-adamantanamine is less potent than mepivacaine, while 2-adamantanamine provokes greater duration of spinal nociceptive block than mepivacaine. Furthermore, 2-adamantanamine demonstrates a more nociceptive-selective action over motor block. (C) 2017 Elsevier B.V. All rights reserved.
Relation:	Neuroscience Letters, v.653, pp.168-172
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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