2-Adamantanamine produces prolonged spinal block in rats

doi:10.1016/j.neulet.2017.05.043

CNU IR > Pharmacy and Science > Dept. of Pharmacy > Periodical Articles > Item 310902800/31737

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/31737

题名:	2-Adamantanamine produces prolonged spinal block in rats
作者:	Chen, Yu-Wen Chen, Chia-Ming Liu, Kuo-Sheng Wang, Jhi-Joung Hung, Ching-Hsia
贡献者:	Chi Mei Med Ctr, Dept Med Res China Med Univ, Dept Phys Therapy, Coll Hlth Care China Med Univ, Grad Inst Rehabil Sci, Coll Hlth Care Chi Mei Med Ctr, Dept Anesthesiol Chia Nan Univ Pharm & Sci, Dept Pharm Natl Cheng Kung Univ, Dept Phys Therapy, Coll Med Natl Cheng Kung Univ, Coll Med, Inst Allied Hlth Sci
关键词:	Intrathecal injection 2-adamantanamine Mepivacairie Nociception Proprioception Motor function
日期:	2017-06-13
上传时间:	2018-11-30 15:54:48 (UTC+8)
出版者:	Elsevier Ireland Ltd
摘要:	We aimed to investigate the local anesthetic effect of 2-adamantanamine in spinal anesthesia. The dose-response curves were constructed after intrathecally injecting the rats with five doses of 2-adamantanamine and a common local anesthetic mepivacaine. The quality and duration of 2-adamantanamine at producing spinal nociceptive, proprioceptive and motor block were compared with that of mepivacaine. We revealed that 2-adamantanamine provoked spinal nociceptive, proprioceptive and motor block dose-dependently. On the 50% effective dose (ED50) basis, the rank of potency was mepivacaine > 2-adamantanamine at producing spinal nociceptive, proprioceptive and motor block (p < 0.05 for the differences). 2-Adamantanamine, but not mepivacaine produced more nociceptive block than motor block (p < 0.05). At the equianesthetic doses (ED75, ED50, and ED25), the nociceptive block duration caused by 2-adamantanamine was greater than that caused by mepivacaine (p < 0.01 for the differences). These preclinical data showed that 2-adamantanamine is less potent than mepivacaine, while 2-adamantanamine provokes greater duration of spinal nociceptive block than mepivacaine. Furthermore, 2-adamantanamine demonstrates a more nociceptive-selective action over motor block. (C) 2017 Elsevier B.V. All rights reserved.
關聯:	Neuroscience Letters, v.653, pp.168-172
显示于类别:	[Dept. of Pharmacy] Periodical Articles

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html		0Kb	HTML	1608	检视/开启

在CNU IR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....