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| 標題: | Anti-Inflammatory and Neuroprotective Constituents from the Peels of Citrus grandis |
| 作者: | Kuo, Ping-Chung
Liao, Yu-Ren
Hung, Hsin-Yi
Chuang, Chia-Wei
Hwang, Tsong-Long
Huang, Shiow-Chyn
Shiao, Young-Ji
Kuo, Daih-Huang
Wu, Tian-Shung |
| 貢獻者: | Natl Cheng Kung Univ, Sch Pharm, Coll Med
Natl Cheng Kung Univ, Dept Chem
Chang Gung Univ, Grad Inst Nat Prod, Coll Med
Chang Gung Univ Sci & Technol, Coll Human Ecol, Res Ctr Food & Cosmet Safety, Res Ctr Chinese Herbal Med
Chang Gung Univ Sci & Technol, Coll Human Ecol, Grad Inst Hlth Ind Technol
Chang Gung Mem Hosp, Dept Anesthesiol
Chia Nan Univ Pharm & Sci, Dept Pharm
Natl Res Inst Chinese Med, Div Basic Chinese Med, Minist Hlth & Welf
Tajen Univ, Dept Pharm, Coll Pharm & Hlth Care |
| 關鍵字: | Citrus grandis
chromatographic method
spectroscopic elucidation
superoxide anion generation
elastase release
neuroprotective |
| 日期: | 2017-06 |
| 上傳時間: | 2018-11-30 15:54:35 (UTC+8) |
| 出版者: | Mdpi Ag |
| 摘要: | A series of chromatographic separations performed on the ethanol extracts of the peels of Citrus grandis has led to the characterization of forty compounds, including seventeen coumarins, eight flavonoids, two triterpenoids, four benzenoids, two steroids, one lignan, one amide, and five other compounds, respectively. The chemical structures of the purified constituents were identified on the basis of spectroscopic elucidation, including 1D- and 2D-NMR, UV, IR, and mass spectrometric analysis. Most of the isolated compounds were examined for their inhibition of superoxide anion generation and elastase release by human neutrophils. Among the isolates, isomeranzin (3), 17,18-dihydroxybergamottin (12), epoxybergamottin (13), rhoifolin (19), vitexicarpin (22) and 4-hydroxybenzaldehyde (29) displayed the most significant inhibition of superoxide anion generation and elastase release with IC50 values ranged from 0.54 to 7.57 mu M, and 0.43 to 4.33 mu M, respectively. In addition, 7-hydroxy-8-(2'-hydroxy-3'-methylbut-3'-enyl)coumarin (8) and 17,18-dihydroxybergamottin (12) also exhibited the protection of neurons against A beta-mediated neurotoxicity at 50 mu M. |
| 關聯: | Molecules, v.22, n.6, pp.967 |
| 顯示於類別: | [藥學系(所)] 期刊論文
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