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    Title: Anti-Inflammatory and Neuroprotective Constituents from the Peels of Citrus grandis
    Authors: Kuo, Ping-Chung
    Liao, Yu-Ren
    Hung, Hsin-Yi
    Chuang, Chia-Wei
    Hwang, Tsong-Long
    Huang, Shiow-Chyn
    Shiao, Young-Ji
    Kuo, Daih-Huang
    Wu, Tian-Shung
    Contributors: Natl Cheng Kung Univ, Sch Pharm, Coll Med
    Natl Cheng Kung Univ, Dept Chem
    Chang Gung Univ, Grad Inst Nat Prod, Coll Med
    Chang Gung Univ Sci & Technol, Coll Human Ecol, Res Ctr Food & Cosmet Safety, Res Ctr Chinese Herbal Med
    Chang Gung Univ Sci & Technol, Coll Human Ecol, Grad Inst Hlth Ind Technol
    Chang Gung Mem Hosp, Dept Anesthesiol
    Chia Nan Univ Pharm & Sci, Dept Pharm
    Natl Res Inst Chinese Med, Div Basic Chinese Med, Minist Hlth & Welf
    Tajen Univ, Dept Pharm, Coll Pharm & Hlth Care
    Keywords: Citrus grandis
    chromatographic method
    spectroscopic elucidation
    superoxide anion generation
    elastase release
    Date: 2017-06
    Issue Date: 2018-11-30 15:54:35 (UTC+8)
    Publisher: Mdpi Ag
    Abstract: A series of chromatographic separations performed on the ethanol extracts of the peels of Citrus grandis has led to the characterization of forty compounds, including seventeen coumarins, eight flavonoids, two triterpenoids, four benzenoids, two steroids, one lignan, one amide, and five other compounds, respectively. The chemical structures of the purified constituents were identified on the basis of spectroscopic elucidation, including 1D- and 2D-NMR, UV, IR, and mass spectrometric analysis. Most of the isolated compounds were examined for their inhibition of superoxide anion generation and elastase release by human neutrophils. Among the isolates, isomeranzin (3), 17,18-dihydroxybergamottin (12), epoxybergamottin (13), rhoifolin (19), vitexicarpin (22) and 4-hydroxybenzaldehyde (29) displayed the most significant inhibition of superoxide anion generation and elastase release with IC50 values ranged from 0.54 to 7.57 mu M, and 0.43 to 4.33 mu M, respectively. In addition, 7-hydroxy-8-(2'-hydroxy-3'-methylbut-3'-enyl)coumarin (8) and 17,18-dihydroxybergamottin (12) also exhibited the protection of neurons against A beta-mediated neurotoxicity at 50 mu M.
    Relation: Molecules, v.22, n.6, pp.967
    Appears in Collections:[Dept. of Pharmacy] Periodical Articles

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