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| 標題: | Chitosan promotes immune responses, ameliorating total mature white blood cell numbers, but increases glutamic oxaloacetic transaminase and glutamic pyruvic transaminase, and ameliorates lactate dehydrogenase levels in leukemia mice in vivo |
| 作者: | Yeh, Ming-Yang
Shih-, Yung-Luen
Chung, Hsueh-Yu
Chou, Jason
Lu, Hsu-Feng
Liu, Chia-Hui
Liu, Jia-You
Huang, Wen-Wen
Peng, Shu-Fen
Wu, Lung-Yuan
Chung, Jing-Gung |
| 貢獻者: | Cheng Hsin Gen Hosp, Off Director
Fu Jen Catholic Univ, Dept Sch Med
Shin Kong Wu Ho Su Mem Hosp, Dept Pathol & Lab Med
Taipei Med Univ, Sch Med Lab Sci & Biotechnol
Jen Teh Jr Coll Med Nursing & Management
Cheng Hsin Gen Hosp, Dept Anat Pathol
Cheng Hsin Gen Hosp, Dept Clin Pathol
Chia Nan Univ Pharm & Sci, Ctr Gen Educ
China Med Univ, Dept Biol Sci & Technol
I Shou Univ, Sch Chinese Med Postbaccalaureate
Asia Univ, Dept Biotechnol |
| 關鍵字: | chitosan
immune response
glutamic oxaloacetic transaminase
glutamic pyruvic transaminase
lactate dehydrogenase |
| 日期: | 2017-09 |
| 上傳時間: | 2018-11-30 15:54:25 (UTC+8) |
| 出版者: | Spandidos Publ Ltd |
| 摘要: | The aim of the present study was to investigate the effect of chitosan (a naturally derived polymer) on the immune responses and glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) and lactate dehydrogenase (LDH) levels in WEHI-3 cell-generated leukemia mice. Mice were divided into control, WEHI-3 control, acetic acid (vehicle) -treated, and 5 and 20 mg/kg chitosan-treated groups. Mice were subsequently weighed, blood was collected, and liver and spleen samples were isolated and weighed. Blood samples were measured for cell markers, the spleen underwent phagocytosis and natural killer (NK) cell activity examination, and cell proliferation was analyzed by flow cytometry. Chitosan did not significantly affect the weights of body, liver and spleen at 5 and 20 mg/kg treatment. Chitosan increased the percentage of CD3 (T cells marker), decreased the levels of CD19 (B-cell marker) and CD11b at 5 mg/kg treatment, and decreased the levels of Mac-3 at 5 and 20 mg/kg treatment. Chitosan significantly increased macrophage phagocytosis of PBMCs, but did not significantly affect macrophage phagocytosis in the peritoneal cavity. Chitosan treatment did not significantly affect the cytotoxic activity of NK cells, and also did not affect T-and B-cell proliferation. Chitosan significantly increased total white blood cell numbers, and GOT and GPT activities were both significantly increased. However, chitosan did not significantly affect LDH activity in leukemia mice. Chitosan may aid in future studies on improving immune responses in the treatment of leukemia. |
| 關聯: | Molecular Medicine Reports, v.16, n.3, pp.2483-2490 |
| 顯示於類別: | [通識教育中心] 期刊論文
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