Constituents from the leaves of Clausena lansium and their anti-inflammatory activity

doi:10.1007/s11418-016-1033-x

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 藥學系(所) > 期刊論文 > Item 310902800/31709

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標題:	Constituents from the leaves of Clausena lansium and their anti-inflammatory activity
作者:	Shen, De-Yang Kuo, Ping-Chung Huang, Shiow-Chyn Hwang, Tsong-Long Chan, Yu-Yi Shieh, Po-Chuen Ngan, Nguyen Thi Thang, Tran Dinh Wu, Tian-Shung
貢獻者:	Natl Cheng Kung Univ, Coll Med, Sch Pharm,Natl Cheng Kung Univ Hosp Chia Nan Univ Pharm & Sci, Dept Pharm Chang Gung Univ, Coll Med, Grad Inst Nat Prod Chang Gung Univ Sci & Technol, Res Ctr Ind Human Ecol, Res Ctr Chinese Herbal Med Chang Gung Univ Sci & Technol, Coll Human Ecol, Grad Inst Hlth Ind Technol Chang Gung Mem Hosp, Dept Anesthesiol Southern Taiwan Univ Sci & Technol, Dept Biotechnol Tajen Univ, Dept Pharm Vinh Univ, Dept Chem
關鍵字:	Clausenalansamide Electronic circular dichroism Single-crystal X-ray diffraction analysis Anti-inflammatory Superoxide anion generation
日期:	2017-01
上傳時間:	2018-11-30 15:53:45 (UTC+8)
出版者:	Springer Japan Kk
摘要:	Five new acyclic amides, clausenalansamides C-G (1-5), clausenaline G (6) and (+/-)-5-(4-methylphenyl)-gamma-valerolactone (7) reported from the natural source for the first time, were characterized from the leaves of Clausena lansium. Their structures were established by spectroscopic and spectrometric methods, and the absolute configurations of new compounds 1-5 were determined by electronic circular dichroism and single-crystal X-ray diffraction analyses. Eighteen compounds were evaluated for their anti-inflammatory activity and only imperatorin (11) and wampetin (12) displayed significant inhibition of fMLP/CB-induced superoxide anion generation with IC50 values of 1.7 +/- 0.3 and 6.8 +/- 1.1 mu M, respectively.
關聯:	Journal of Natural Medicines, v.71, n.1, pp.96-104
显示于类别:	[藥學系(所)] 期刊論文

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