Constituents from the leaves of Clausena lansium and their anti-inflammatory activity

doi:10.1007/s11418-016-1033-x

CNU IR > Pharmacy and Science > Dept. of Pharmacy > Periodical Articles > Item 310902800/31709

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/31709

Title:	Constituents from the leaves of Clausena lansium and their anti-inflammatory activity
Authors:	Shen, De-Yang Kuo, Ping-Chung Huang, Shiow-Chyn Hwang, Tsong-Long Chan, Yu-Yi Shieh, Po-Chuen Ngan, Nguyen Thi Thang, Tran Dinh Wu, Tian-Shung
Contributors:	Natl Cheng Kung Univ, Coll Med, Sch Pharm,Natl Cheng Kung Univ Hosp Chia Nan Univ Pharm & Sci, Dept Pharm Chang Gung Univ, Coll Med, Grad Inst Nat Prod Chang Gung Univ Sci & Technol, Res Ctr Ind Human Ecol, Res Ctr Chinese Herbal Med Chang Gung Univ Sci & Technol, Coll Human Ecol, Grad Inst Hlth Ind Technol Chang Gung Mem Hosp, Dept Anesthesiol Southern Taiwan Univ Sci & Technol, Dept Biotechnol Tajen Univ, Dept Pharm Vinh Univ, Dept Chem
Keywords:	Clausenalansamide Electronic circular dichroism Single-crystal X-ray diffraction analysis Anti-inflammatory Superoxide anion generation
Date:	2017-01
Issue Date:	2018-11-30 15:53:45 (UTC+8)
Publisher:	Springer Japan Kk
Abstract:	Five new acyclic amides, clausenalansamides C-G (1-5), clausenaline G (6) and (+/-)-5-(4-methylphenyl)-gamma-valerolactone (7) reported from the natural source for the first time, were characterized from the leaves of Clausena lansium. Their structures were established by spectroscopic and spectrometric methods, and the absolute configurations of new compounds 1-5 were determined by electronic circular dichroism and single-crystal X-ray diffraction analyses. Eighteen compounds were evaluated for their anti-inflammatory activity and only imperatorin (11) and wampetin (12) displayed significant inhibition of fMLP/CB-induced superoxide anion generation with IC50 values of 1.7 +/- 0.3 and 6.8 +/- 1.1 mu M, respectively.
Relation:	Journal of Natural Medicines, v.71, n.1, pp.96-104
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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