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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/31705

    標題: The Root Extract of Gentiana macrophylla Pall. Alleviates B19-NS1-Exacerbated Liver Injuries in NZB/W F1 Mice
    作者: Sheu, Ming-Jen
    Chiu, Chun-Ching
    Yang, Deng-Jye
    Hsu, Tsai-Ching
    Tzang, Bor-Show
    貢獻者: Chi Mei Med Ctr, Div Gastroenterol & Hepatol
    Chia Nan Univ Pharm & Sci, Dept Med Chem
    Chunghua Christian Hosp, Dept Neurol
    Chunghua Christian Hosp, Dept Med Intens Care Unit
    China Med Univ, Dept Nutr
    Chung Shan Med Univ, Inst Biochem Microbiol & Immunol
    Chung Shan Med Univ Hosp, Clin Lab
    Chung Shan Med Univ, Immunol Res Ctr
    Chung Shan Med Univ, Sch Med, Dept Biochem
    關鍵字: Gentiana macrophylla Pall. (GM)
    human parvovirus B19 (B19)
    liver inflammation
    nonstructure protein NS1
    systematic lupus erythomatosus (SLE)
    日期: 2017-01
    上傳時間: 2018-11-30 15:53:36 (UTC+8)
    出版者: Mary Ann Liebert, Inc
    摘要: The nonstructural protein NS1 of human parvovirus B19 (B19) is known to exacerbate disease activity in systemic lupus erythematosus (SLE). However, no specific medicine for B19 infection is available. The roots of Gentiana macrophylla Pall. (GM), the traditional Chinese medicine &quot;Qinjiao,'' have been used for centuries to treat rheumatic disease, including SLE. Herein, we aimed to investigate the effects of GM root extract (100 and 300 mg/kg body weight) on B19-NS1-exacerbated liver injury in NZB/W F1 mice; liver tissues were assessed by hematoxylin-eosin staining and immunoblotting. The GM root extract significantly decreased B19-NS1-exacerbated liver inflammation by suppressing the expressions of hepatic inducible nitric oxide synthase, cyclooxygenase type 2 (COX-2), interleukin (IL)-1 beta proteins, values of serum asparate transaminase (AST) and alanine transaminase (ALT), and lymphocyte infiltration (P < .05). It also significantly reduced the B19-NS1-exacerbated hepatic matrix metalloproteinase-9 (MMP-9) and urokinase plasminogen activator (uPA) expressions by downregulating tumor necrosis factor (TNF)-alpha/NF-kappa B (p65) signaling. These findings suggest a therapeutic potential of GM root extract against B19-NS1-exacerbated liver inflammation in SLE.
    關聯: Journal of Medicinal Food, v.20, n.1, pp.56-64
    Appears in Collections:[醫藥化學系 ] 期刊論文

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