The Root Extract of Gentiana macrophylla Pall. Alleviates B19-NS1-Exacerbated Liver Injuries in NZB/W F1 Mice

doi:10.1089/jmf.2016.3817

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 食藥產業暨檢測科技系(含五專) > 期刊論文 > Item 310902800/31705

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標題:	The Root Extract of Gentiana macrophylla Pall. Alleviates B19-NS1-Exacerbated Liver Injuries in NZB/W F1 Mice
作者:	Sheu, Ming-Jen Chiu, Chun-Ching Yang, Deng-Jye Hsu, Tsai-Ching Tzang, Bor-Show
貢獻者:	Chi Mei Med Ctr, Div Gastroenterol & Hepatol Chia Nan Univ Pharm & Sci, Dept Med Chem Chunghua Christian Hosp, Dept Neurol Chunghua Christian Hosp, Dept Med Intens Care Unit China Med Univ, Dept Nutr Chung Shan Med Univ, Inst Biochem Microbiol & Immunol Chung Shan Med Univ Hosp, Clin Lab Chung Shan Med Univ, Immunol Res Ctr Chung Shan Med Univ, Sch Med, Dept Biochem
關鍵字:	Gentiana macrophylla Pall. (GM) human parvovirus B19 (B19) liver inflammation nonstructure protein NS1 systematic lupus erythomatosus (SLE)
日期:	2017-01
上傳時間:	2018-11-30 15:53:36 (UTC+8)
出版者:	Mary Ann Liebert, Inc
摘要:	The nonstructural protein NS1 of human parvovirus B19 (B19) is known to exacerbate disease activity in systemic lupus erythematosus (SLE). However, no specific medicine for B19 infection is available. The roots of Gentiana macrophylla Pall. (GM), the traditional Chinese medicine "Qinjiao,'' have been used for centuries to treat rheumatic disease, including SLE. Herein, we aimed to investigate the effects of GM root extract (100 and 300 mg/kg body weight) on B19-NS1-exacerbated liver injury in NZB/W F1 mice; liver tissues were assessed by hematoxylin-eosin staining and immunoblotting. The GM root extract significantly decreased B19-NS1-exacerbated liver inflammation by suppressing the expressions of hepatic inducible nitric oxide synthase, cyclooxygenase type 2 (COX-2), interleukin (IL)-1 beta proteins, values of serum asparate transaminase (AST) and alanine transaminase (ALT), and lymphocyte infiltration (P < .05). It also significantly reduced the B19-NS1-exacerbated hepatic matrix metalloproteinase-9 (MMP-9) and urokinase plasminogen activator (uPA) expressions by downregulating tumor necrosis factor (TNF)-alpha/NF-kappa B (p65) signaling. These findings suggest a therapeutic potential of GM root extract against B19-NS1-exacerbated liver inflammation in SLE.
關聯:	Journal of Medicinal Food, v.20, n.1, pp.56-64
顯示於類別:	[食藥產業暨檢測科技系(含五專)] 期刊論文

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