The Root Extract of Gentiana macrophylla Pall. Alleviates B19-NS1-Exacerbated Liver Injuries in NZB/W F1 Mice

doi:10.1089/jmf.2016.3817

CNU IR > Pharmacy and Science > Dept. of Food & Drug Industry and Inspective Technology > Periodical Articles > Item 310902800/31705

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/31705

Title:	The Root Extract of Gentiana macrophylla Pall. Alleviates B19-NS1-Exacerbated Liver Injuries in NZB/W F1 Mice
Authors:	Sheu, Ming-Jen Chiu, Chun-Ching Yang, Deng-Jye Hsu, Tsai-Ching Tzang, Bor-Show
Contributors:	Chi Mei Med Ctr, Div Gastroenterol & Hepatol Chia Nan Univ Pharm & Sci, Dept Med Chem Chunghua Christian Hosp, Dept Neurol Chunghua Christian Hosp, Dept Med Intens Care Unit China Med Univ, Dept Nutr Chung Shan Med Univ, Inst Biochem Microbiol & Immunol Chung Shan Med Univ Hosp, Clin Lab Chung Shan Med Univ, Immunol Res Ctr Chung Shan Med Univ, Sch Med, Dept Biochem
Keywords:	Gentiana macrophylla Pall. (GM) human parvovirus B19 (B19) liver inflammation nonstructure protein NS1 systematic lupus erythomatosus (SLE)
Date:	2017-01
Issue Date:	2018-11-30 15:53:36 (UTC+8)
Publisher:	Mary Ann Liebert, Inc
Abstract:	The nonstructural protein NS1 of human parvovirus B19 (B19) is known to exacerbate disease activity in systemic lupus erythematosus (SLE). However, no specific medicine for B19 infection is available. The roots of Gentiana macrophylla Pall. (GM), the traditional Chinese medicine "Qinjiao,'' have been used for centuries to treat rheumatic disease, including SLE. Herein, we aimed to investigate the effects of GM root extract (100 and 300 mg/kg body weight) on B19-NS1-exacerbated liver injury in NZB/W F1 mice; liver tissues were assessed by hematoxylin-eosin staining and immunoblotting. The GM root extract significantly decreased B19-NS1-exacerbated liver inflammation by suppressing the expressions of hepatic inducible nitric oxide synthase, cyclooxygenase type 2 (COX-2), interleukin (IL)-1 beta proteins, values of serum asparate transaminase (AST) and alanine transaminase (ALT), and lymphocyte infiltration (P < .05). It also significantly reduced the B19-NS1-exacerbated hepatic matrix metalloproteinase-9 (MMP-9) and urokinase plasminogen activator (uPA) expressions by downregulating tumor necrosis factor (TNF)-alpha/NF-kappa B (p65) signaling. These findings suggest a therapeutic potential of GM root extract against B19-NS1-exacerbated liver inflammation in SLE.
Relation:	Journal of Medicinal Food, v.20, n.1, pp.56-64
Appears in Collections:	[Dept. of Food & Drug Industry and Inspective Technology] Periodical Articles

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