Overexpression of Mitochondrial GTPase MFN2 Represents a Negative Prognostic Marker in Human Gastric Cancer and Its Inhibition Exerts Anti-Cancer Effects

doi:10.7150/jca.17986

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標題:	Overexpression of Mitochondrial GTPase MFN2 Represents a Negative Prognostic Marker in Human Gastric Cancer and Its Inhibition Exerts Anti-Cancer Effects
作者:	Fang, Chia-Lang Sun, Ding-Ping Chen, Han-Kun Lin, Chih-Chan Hung, Shih-Ting Uen, Yih-Huei Lin, Kai-Yuan
貢獻者:	Taipei Med Univ, Sch Med, Dept Pathol, Coll Med Taipei Med Univ, Wan Fang Hosp, Dept Pathol Chi Mei Med Ctr, Dept Surg Chia Nan Univ Pharm & Sci, Dept Nutr Chi Mei Med Ctr, Dept Med Res Chi Mei Hosp Chiali, Superintendents Off Chia Nan Univ Pharm & Sci, Dept Biotechnol
關鍵字:	gastric cancer MFN2 prognosis
日期:	2017
上傳時間:	2018-11-30 15:52:54 (UTC+8)
出版者:	Ivyspring Int Publ
摘要:	Background: As one of the most common malignancies in the world, little is known about the molecular mechanism underlying gastric cancer (GC) and its progression. In this study, we aimed to investigate the clinical impact of the mitochondrial GTPase mitofusin 2 (MFN2) in GC. Methods: Immunohistochemistry was used to examine the expression levels of MFN2 in gastric tissues obtained from 141 patients with GC. The correlations between MFN2 protein level and clinicopathologic parameters, as well as the significance of MFN2 protein level for overall and disease-free survival were assessed. siRNA technology was used to study the effect of MFN2 knockdown on cell proliferation and invasion. Results: The overexpression of MFN2 was positively associated with depth of invasion (P = 0.0430), stage (P = 0.0325) and vascular invasion (P = 0.0077). Patients with high expression levels of MFN2 had a significantly lower overall survival rate and disease-free survival rate compared with those with low expression levels (P = 0.003 and 0.001, respectively). Multivariate Cox regression analysis showed that the overexpression of MFN2 was an independent prognostic marker for inferior overall survival and disease-free survival (P = 0.015 and 0.025, respectively). In addition, studies conducted in GC cells indicated that knockdown of MFN2 suppressed cell proliferation and invasion. Conclusions: Overexpression of MFN2 can be used as a marker to predict the outcome of patients with GC. Furthermore, targeting MFN2 might provide a new therapeutic modality for the treatment of GC.
關聯:	Journal of Cancer, v.8, n.7, pp.1153-1161
显示于类别:	[生物科技系(所)] 期刊論文 [保健營養系(所) ] 期刊論文

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