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    Title: Overexpression of Mitochondrial GTPase MFN2 Represents a Negative Prognostic Marker in Human Gastric Cancer and Its Inhibition Exerts Anti-Cancer Effects
    Authors: Fang, Chia-Lang
    Sun, Ding-Ping
    Chen, Han-Kun
    Lin, Chih-Chan
    Hung, Shih-Ting
    Uen, Yih-Huei
    Lin, Kai-Yuan
    Contributors: Taipei Med Univ, Sch Med, Dept Pathol, Coll Med
    Taipei Med Univ, Wan Fang Hosp, Dept Pathol
    Chi Mei Med Ctr, Dept Surg
    Chia Nan Univ Pharm & Sci, Dept Nutr
    Chi Mei Med Ctr, Dept Med Res
    Chi Mei Hosp Chiali, Superintendents Off
    Chia Nan Univ Pharm & Sci, Dept Biotechnol
    Keywords: gastric cancer
    Date: 2017
    Issue Date: 2018-11-30 15:52:54 (UTC+8)
    Publisher: Ivyspring Int Publ
    Abstract: Background: As one of the most common malignancies in the world, little is known about the molecular mechanism underlying gastric cancer (GC) and its progression. In this study, we aimed to investigate the clinical impact of the mitochondrial GTPase mitofusin 2 (MFN2) in GC. Methods: Immunohistochemistry was used to examine the expression levels of MFN2 in gastric tissues obtained from 141 patients with GC. The correlations between MFN2 protein level and clinicopathologic parameters, as well as the significance of MFN2 protein level for overall and disease-free survival were assessed. siRNA technology was used to study the effect of MFN2 knockdown on cell proliferation and invasion. Results: The overexpression of MFN2 was positively associated with depth of invasion (P = 0.0430), stage (P = 0.0325) and vascular invasion (P = 0.0077). Patients with high expression levels of MFN2 had a significantly lower overall survival rate and disease-free survival rate compared with those with low expression levels (P = 0.003 and 0.001, respectively). Multivariate Cox regression analysis showed that the overexpression of MFN2 was an independent prognostic marker for inferior overall survival and disease-free survival (P = 0.015 and 0.025, respectively). In addition, studies conducted in GC cells indicated that knockdown of MFN2 suppressed cell proliferation and invasion. Conclusions: Overexpression of MFN2 can be used as a marker to predict the outcome of patients with GC. Furthermore, targeting MFN2 might provide a new therapeutic modality for the treatment of GC.
    Relation: Journal of Cancer, v.8, n.7, pp.1153-1161
    Appears in Collections:[Dept. of Biotechnology (including master's program)] Periodical Articles
    [Dept. of Health and Nutrition (including master's program)] Periodical Articles

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