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Please use this identifier to cite or link to this item:
https://ir.cnu.edu.tw/handle/310902800/31683
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Title: | New insights into Blimp-1 in T lymphocytes: a divergent regulator of cell destiny and effector function |
Authors: | Fu, Shin-Huei Yeh, Li-Tzu Chu, Chin-Chen Yen, B. Lin-Ju Sytwu, Huey-Kang |
Contributors: | Natl Def Med Ctr, Dept & Grad Inst Microbiol & Immunol Chi Mei Med Ctr, Dept Anesthesiol Chia Nan Univ Pharm & Sci, Dept Recreat & Hlth Care Management Natl Hlth Res Inst, Inst Cellular & Syst Med |
Keywords: | Blimp-1 Prdm1 Bcl-6 CD4(+) T lymphocytes CD8(+) T lymphocytes T helper cells Regulatory T cells T follicular helper cells Interleukins STATs |
Date: | 2017-07-21 |
Issue Date: | 2018-11-30 15:52:45 (UTC+8) |
Publisher: | Biomed Central Ltd |
Abstract: | B lymphocyte-induced maturation protein-1 (Blimp-1) serves as a master regulator of the development and function of antibody-producing B cells. Given that its function in T lymphocytes has been identified within the past decade, we review recent findings with emphasis on its role in coordinated control of gene expression during the development, differentiation, and function of T cells. Expression of Blimp-1 is mainly confined to activated T cells and is essential for the production of interleukin (IL)-10 by a subset of forkhead box (Fox)p3(+) regulatory T cells with an effector phenotype. Blimp-1 is also required to induce cell elimination in the thymus and critically modulates peripheral T cell activation and proliferation. In addition, Blimp-1 promotes T helper (Th) 2 lineage commitment and limits Th1, Th17 and follicular helper T cell differentiation. Furthermore, Blimp-1 coordinates with other transcription factors to regulate expression of IL-2, IL-21 and IL-10 in effector T lymphocytes. In CD8(+) T cells, Blimp-1 expression is distinct in heterogeneous populations at the stages of clonal expansion, differentiation, contraction and memory formation when they encounter antigens. Moreover, Blimp-1 plays a fundamental role in coordinating cytokine receptor signaling networks and transcriptional programs to regulate diverse aspects of the formation and function of effector and memory CD8(+) T cells and their exhaustion. Blimp-1 also functions as a gatekeeper of T cell activation and suppression to prevent or dampen autoimmune disease, antiviral responses and antitumor immunity. In this review, we discuss the emerging roles of Blimp-1 in the complex regulation of gene networks that regulate the destiny and effector function of T cells and provide a Blimp-1-dominated transcriptional framework for T lymphocyte homeostasis. |
Relation: | Journal of Biomedical Science, v.24, pp.49 |
Appears in Collections: | [Dept. of Recreation and Health-Care Management] Periodical Articles
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10.1186-s12929-017-0354-8.pdf | | 1242Kb | Adobe PDF | 0 | View/Open | index.html | | 0Kb | HTML | 1111 | View/Open |
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