New insights into Blimp-1 in T lymphocytes: a divergent regulator of cell destiny and effector function

doi:10.1186/s12929-017-0354-8

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標題:	New insights into Blimp-1 in T lymphocytes: a divergent regulator of cell destiny and effector function
作者:	Fu, Shin-Huei Yeh, Li-Tzu Chu, Chin-Chen Yen, B. Lin-Ju Sytwu, Huey-Kang
貢獻者:	Natl Def Med Ctr, Dept & Grad Inst Microbiol & Immunol Chi Mei Med Ctr, Dept Anesthesiol Chia Nan Univ Pharm & Sci, Dept Recreat & Hlth Care Management Natl Hlth Res Inst, Inst Cellular & Syst Med
關鍵字:	Blimp-1 Prdm1 Bcl-6 CD4(+) T lymphocytes CD8(+) T lymphocytes T helper cells Regulatory T cells T follicular helper cells Interleukins STATs
日期:	2017-07-21
上傳時間:	2018-11-30 15:52:45 (UTC+8)
出版者:	Biomed Central Ltd
摘要:	B lymphocyte-induced maturation protein-1 (Blimp-1) serves as a master regulator of the development and function of antibody-producing B cells. Given that its function in T lymphocytes has been identified within the past decade, we review recent findings with emphasis on its role in coordinated control of gene expression during the development, differentiation, and function of T cells. Expression of Blimp-1 is mainly confined to activated T cells and is essential for the production of interleukin (IL)-10 by a subset of forkhead box (Fox)p3(+) regulatory T cells with an effector phenotype. Blimp-1 is also required to induce cell elimination in the thymus and critically modulates peripheral T cell activation and proliferation. In addition, Blimp-1 promotes T helper (Th) 2 lineage commitment and limits Th1, Th17 and follicular helper T cell differentiation. Furthermore, Blimp-1 coordinates with other transcription factors to regulate expression of IL-2, IL-21 and IL-10 in effector T lymphocytes. In CD8(+) T cells, Blimp-1 expression is distinct in heterogeneous populations at the stages of clonal expansion, differentiation, contraction and memory formation when they encounter antigens. Moreover, Blimp-1 plays a fundamental role in coordinating cytokine receptor signaling networks and transcriptional programs to regulate diverse aspects of the formation and function of effector and memory CD8(+) T cells and their exhaustion. Blimp-1 also functions as a gatekeeper of T cell activation and suppression to prevent or dampen autoimmune disease, antiviral responses and antitumor immunity. In this review, we discuss the emerging roles of Blimp-1 in the complex regulation of gene networks that regulate the destiny and effector function of T cells and provide a Blimp-1-dominated transcriptional framework for T lymphocyte homeostasis.
關聯:	Journal of Biomedical Science, v.24, pp.49
显示于类别:	[休閒保健管理系(所)] 期刊論文

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