Coexistence of MCR-1 and NDM-9 in a clinical carbapenem-resistant Escherichia coli isolate

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標題:	Coexistence of MCR-1 and NDM-9 in a clinical carbapenem-resistant Escherichia coli isolate
作者:	Lai, Chih-Cheng Chuang, Yin-Ching Chen, Chi-Chung Tang, Hung-Jen
貢獻者:	Chi Mei Med Ctr, Dept Intens Care Med Chi Mei Med Ctr, Dept Med Res Chi Mei Med Ctr, Dept Internal Med Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Chi Mei Med Ctr, Dept Med
日期:	2017-04
上傳時間:	2018-11-30 15:52:03 (UTC+8)
出版者:	Elsevier Science Bv
摘要:	Since New Delhi metallo-β-lactamase-1 (NDM-1) was first detected [1], several variants have been further identified that differ by one or two amino acid substitutions. In 2014, a novel NDM-9 metallo-β-lactamase was first identified from a sequence type 107 (ST107) Klebsiella pneumoniae strain [2]. Like the other NDM variants, NDM-9 confers high levels of resistance and compromises the effectiveness of most antibiotics, including carbapenems [2–4]. Although polymyxin B and colistin (polymyxin E) offer limited treatment options for multidrug-resistant (MDR) organisms carrying NDM-9, the emergence of the plasmid-mediated colistin resistance gene mcr-1 (for mobilised colistin resistance gene) conferring resistance to colistin (polymyxin E) may attenuate the utility of colistin.
關聯:	International Journal of Antimicrobial Agents, v.49, n.4, pp.517-518
顯示於類別:	[保健營養系(所) ] 期刊論文

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