Coexistence of MCR-1 and NDM-9 in a clinical carbapenem-resistant Escherichia coli isolate

CNU IR > Pharmacy and Science > Dept. of Health and Nutrition (including master's program) > Periodical Articles > Item 310902800/31664

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/31664

Title:	Coexistence of MCR-1 and NDM-9 in a clinical carbapenem-resistant Escherichia coli isolate
Authors:	Lai, Chih-Cheng Chuang, Yin-Ching Chen, Chi-Chung Tang, Hung-Jen
Contributors:	Chi Mei Med Ctr, Dept Intens Care Med Chi Mei Med Ctr, Dept Med Res Chi Mei Med Ctr, Dept Internal Med Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Chi Mei Med Ctr, Dept Med
Date:	2017-04
Issue Date:	2018-11-30 15:52:03 (UTC+8)
Publisher:	Elsevier Science Bv
Abstract:	Since New Delhi metallo-β-lactamase-1 (NDM-1) was first detected [1], several variants have been further identified that differ by one or two amino acid substitutions. In 2014, a novel NDM-9 metallo-β-lactamase was first identified from a sequence type 107 (ST107) Klebsiella pneumoniae strain [2]. Like the other NDM variants, NDM-9 confers high levels of resistance and compromises the effectiveness of most antibiotics, including carbapenems [2–4]. Although polymyxin B and colistin (polymyxin E) offer limited treatment options for multidrug-resistant (MDR) organisms carrying NDM-9, the emergence of the plasmid-mediated colistin resistance gene mcr-1 (for mobilised colistin resistance gene) conferring resistance to colistin (polymyxin E) may attenuate the utility of colistin.
Relation:	International Journal of Antimicrobial Agents, v.49, n.4, pp.517-518
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	1272	View/Open