Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/31664
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    Title: Coexistence of MCR-1 and NDM-9 in a clinical carbapenem-resistant Escherichia coli isolate
    Authors: Lai, Chih-Cheng
    Chuang, Yin-Ching
    Chen, Chi-Chung
    Tang, Hung-Jen
    Contributors: Chi Mei Med Ctr, Dept Intens Care Med
    Chi Mei Med Ctr, Dept Med Res
    Chi Mei Med Ctr, Dept Internal Med
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    Chi Mei Med Ctr, Dept Med
    Date: 2017-04
    Issue Date: 2018-11-30 15:52:03 (UTC+8)
    Publisher: Elsevier Science Bv
    Abstract: Since New Delhi metallo-β-lactamase-1 (NDM-1) was first detected [1], several variants have been further identified that differ by one or two amino acid substitutions. In 2014, a novel NDM-9 metallo-β-lactamase was first identified from a sequence type 107 (ST107) Klebsiella pneumoniae strain [2]. Like the other NDM variants, NDM-9 confers high levels of resistance and compromises the effectiveness of most antibiotics, including carbapenems [2–4]. Although polymyxin B and colistin (polymyxin E) offer limited treatment options for multidrug-resistant (MDR) organisms carrying NDM-9, the emergence of the plasmid-mediated colistin resistance gene mcr-1 (for mobilised colistin resistance gene) conferring resistance to colistin (polymyxin E) may attenuate the utility of colistin.
    Relation: International Journal of Antimicrobial Agents, v.49, n.4, pp.517-518
    Appears in Collections:[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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