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| 標題: | Coexistence of MCR-1 and NDM-9 in a clinical carbapenem-resistant Escherichia coli isolate |
| 作者: | Lai, Chih-Cheng
Chuang, Yin-Ching
Chen, Chi-Chung
Tang, Hung-Jen |
| 貢獻者: | Chi Mei Med Ctr, Dept Intens Care Med
Chi Mei Med Ctr, Dept Med Res
Chi Mei Med Ctr, Dept Internal Med
Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
Chi Mei Med Ctr, Dept Med |
| 日期: | 2017-04 |
| 上傳時間: | 2018-11-30 15:52:03 (UTC+8) |
| 出版者: | Elsevier Science Bv |
| 摘要: | Since New Delhi metallo-β-lactamase-1 (NDM-1) was first detected [1], several variants have been further identified that differ by one or two amino acid substitutions. In 2014, a novel NDM-9 metallo-β-lactamase was first identified from a sequence type 107 (ST107) Klebsiella pneumoniae strain [2]. Like the other NDM variants, NDM-9 confers high levels of resistance and compromises the effectiveness of most antibiotics, including carbapenems [2–4]. Although polymyxin B and colistin (polymyxin E) offer limited treatment options for multidrug-resistant (MDR) organisms carrying NDM-9, the emergence of the plasmid-mediated colistin resistance gene mcr-1 (for mobilised colistin resistance gene) conferring resistance to colistin (polymyxin E) may attenuate the utility of colistin. |
| 關聯: | International Journal of Antimicrobial Agents, v.49, n.4, pp.517-518 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
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