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| 標題: | Anticancer Effects of Salvia miltiorrhiza Alcohol Extract on Oral Squamous Carcinoma Cells |
| 作者: | Wang, Wen-Hung
Hsuan, Kuo-Yu
Chu, Ling-Ya
Lee, Chia-Ying
Tyan, Yu-Chang
Chen, Zong-Shiow
Tsai, Wan-Chi |
| 貢獻者: | Cathay Gen Hosp, Dept Otolaryngol
SijhihCathay Gen Hosp, Dept Otolaryngol
Fu Jen Catholic Univ, Sch Med
Chi Mei Med Ctr, Dept Hematooncol
Kaohsiung Med Univ, Dept Med Lab Sci & Biotechnol
Kaohsiung Med Univ, Dept Med Imaging & Radiol Sci
Kaohsiung Med Univ, Ctr Infect Dis & Canc Res
Kaohsiung Med Univ, Coll Med, Grad Inst Med
Natl Sun Yat Sen Univ, Inst Med Sci & Technol
Kaohsiung Med Univ Hosp, Dept Med Res
Chia Nan Univ Pharm & Sci, Inst Cosmet Sci |
| 關鍵字: | In-Vitro
Tanshinone Iia
Acid-B
Breast-Cancer
Apoptosis
Proliferation
Inhibition
Expression
Caspase-3
Pathways |
| 日期: | 2017 |
| 上傳時間: | 2018-11-30 15:51:20 (UTC+8) |
| 出版者: | Hindawi Ltd |
| 摘要: | Researchers have reported significant effects from Danshen (Salvia miltiorrhiza) in terms of inhibiting tumor cell proliferation and promoting apoptosis in breast cancer, hepatocellular carcinomas, promyelocytic leukemia, and clear cell ovary carcinomas. Here we report our data indicating that Danshen extracts, especially alcohol extract, significantly inhibited the proliferation of the human oral squamous carcinoma (OSCC) cell lines HSC-3 and OC-2. We also observed that Danshen alcohol extract activated the caspase-3 apoptosis executor by impeding members of the inhibitor of apoptosis (IAP) family, but not by regulating the Bcl-2-triggered mitochondrial pathway in OSCC cells. Our data also indicate that the extract exerted promising effects in vivo, with HSC-3 tumor xenograft growth being suppressed by 40% and 69% following treatment with Danshen alcohol extract at 50 and 100mg/kg, respectively, for 34 days. Combined, our results indicate appreciable anticancer activity and significant potential for Danshen alcohol extract as a natural antioxidant and herbal human oral cancer chemopreventive drug. |
| 關聯: | Evidence-Based Complementary and Alternative Medicine, v.2017, 文獻號碼:5364010 |
| 顯示於類別: | [化妝品應用與管理系(所)] 期刊論文
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