Anticancer Effects of Salvia miltiorrhiza Alcohol Extract on Oral Squamous Carcinoma Cells

doi:10.1155/2017/5364010

CNU IR > Pharmacy and Science > Dept. of Cosmetic Science and institute of cosmetic science > Periodical Articles > Item 310902800/31644

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/31644

Title:	Anticancer Effects of Salvia miltiorrhiza Alcohol Extract on Oral Squamous Carcinoma Cells
Authors:	Wang, Wen-Hung Hsuan, Kuo-Yu Chu, Ling-Ya Lee, Chia-Ying Tyan, Yu-Chang Chen, Zong-Shiow Tsai, Wan-Chi
Contributors:	Cathay Gen Hosp, Dept Otolaryngol SijhihCathay Gen Hosp, Dept Otolaryngol Fu Jen Catholic Univ, Sch Med Chi Mei Med Ctr, Dept Hematooncol Kaohsiung Med Univ, Dept Med Lab Sci & Biotechnol Kaohsiung Med Univ, Dept Med Imaging & Radiol Sci Kaohsiung Med Univ, Ctr Infect Dis & Canc Res Kaohsiung Med Univ, Coll Med, Grad Inst Med Natl Sun Yat Sen Univ, Inst Med Sci & Technol Kaohsiung Med Univ Hosp, Dept Med Res Chia Nan Univ Pharm & Sci, Inst Cosmet Sci
Keywords:	In-Vitro Tanshinone Iia Acid-B Breast-Cancer Apoptosis Proliferation Inhibition Expression Caspase-3 Pathways
Date:	2017
Issue Date:	2018-11-30 15:51:20 (UTC+8)
Publisher:	Hindawi Ltd
Abstract:	Researchers have reported significant effects from Danshen (Salvia miltiorrhiza) in terms of inhibiting tumor cell proliferation and promoting apoptosis in breast cancer, hepatocellular carcinomas, promyelocytic leukemia, and clear cell ovary carcinomas. Here we report our data indicating that Danshen extracts, especially alcohol extract, significantly inhibited the proliferation of the human oral squamous carcinoma (OSCC) cell lines HSC-3 and OC-2. We also observed that Danshen alcohol extract activated the caspase-3 apoptosis executor by impeding members of the inhibitor of apoptosis (IAP) family, but not by regulating the Bcl-2-triggered mitochondrial pathway in OSCC cells. Our data also indicate that the extract exerted promising effects in vivo, with HSC-3 tumor xenograft growth being suppressed by 40% and 69% following treatment with Danshen alcohol extract at 50 and 100mg/kg, respectively, for 34 days. Combined, our results indicate appreciable anticancer activity and significant potential for Danshen alcohol extract as a natural antioxidant and herbal human oral cancer chemopreventive drug.
Relation:	Evidence-Based Complementary and Alternative Medicine, v.2017, 文獻號碼:5364010
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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