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| 標題: | Effect of enterovirus infections on asthma in young children: Anational cohort study |
| 作者: | Yeh, Jun-Jun
Lin, Cheng-Li
Hsu, Wu-Huei |
| 貢獻者: | Chia Yi Christian Hosp, Dept Family Med,Ditmanson Med Fdn
Chia Nan Univ Pharm & Sci
Meiho Univ
China Med Univ Hosp, Management Off Hlth Data
China Med Univ, Coll Med
China Med Univ, Grad Inst Clin Med Sci, Coll Med
China Med Univ, Sch Med, Coll Med
China Med Univ Hosp, Div Pulm & Crit Care Med, Dept Internal Med |
| 關鍵字: | asthma
cohort study
enterovirus |
| 日期: | 2017-12 |
| 上傳時間: | 2018-11-30 15:51:16 (UTC+8) |
| 出版者: | Wiley |
| 摘要: | BackgroundWe conducted a cohort study to determine the relationship between enterovirus (EV) infection and asthma. Materials and methodsFrom the National Health Insurance Research Database of Taiwan, we identified patients who received a new diagnosis of asthma and concurrent treatment between January 2000 and December 2011 (EV cohort: n=208213; non-EV cohort: n=208213). Cox proportional hazards regression analysis was performed to determine and compare the adjusted hazard ratios (aHRs) of asthma between these 2 cohorts. Kaplan-Meier analysis was conducted to assess the differences in the cumulative incidence curves of asthma between the 2 cohorts. ResultsThe overall aHR of asthma was 1.48-fold higher in the EV cohort than in the non-EV cohort (95% confidence interval=1.45-1.50). The aHR of asthma was higher in the EV cohort than in the non-EV cohort, comprising children aged 5years, regardless of sex, sociodemographic factors (urbanization level and parental occupation) or comorbidities. The risk of asthma was higher in 1-3, 4-6, 7-9 and 10-12months (all P<.001), particularly in those with a higher frequency of admission (>5 per year). ConclusionThe incidence of asthma was higher in the EV cohort than in the non-EV cohort, comprising children aged 5years, regardless of sex, urbanization level, parental occupation or season. In particular, the risk of asthma was higher in children with a higher frequency of admission, even in the absence of atopy or other respiratory infections. |
| 關聯: | European Journal of Clinical Investigation, v.47, n.12, 文獻號碼:UNSP e12844 |
| 顯示於類別: | [嬰幼兒保育系] 期刊論文
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