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| 標題: | Association of asthma-chronic obstructive pulmonary disease overlap syndrome with coronary artery disease, cardiac dysrhythmia and heart failure: a population-based retrospective cohort study |
| 作者: | Yeh, Jun-Jun
Wei, Yu-Feng
Lin, Cheng-Li
Hsu, Wu-Huei |
| 貢獻者: | Chia Yi Christian Hosp,Ditmanson Med Fdn, Dept Chest Med Family Med & Geriatr Med
Meiho Univ
Chia Nan Univ Pharm & Sci
Heng Chun Christian Hosp
I Shou Univ, E Da Hosp, Dept Internal Med
China Med Univ Hosp, Management Off Hlth Data
China Med Univ, Coll Med
China Med Univ, Coll Med, Grad Inst Clin Med Sci
China Med Univ, Coll Med, Sch Med
China Med Univ Hosp, Dept Internal Med, Div Pulm & Crit Care Med |
| 關鍵字: | Systemic Inflammation
Beta-Blockers
Copd
Impact
Exacerbations
Outcomes
Comorbidities
Hypertension
Carvedilol
Mortality |
| 日期: | 2017-10 |
| 上傳時間: | 2018-11-30 15:49:59 (UTC+8) |
| 出版者: | Bmj Publishing Group |
| 摘要: | Objectives Patients with asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) and cardiovascular diseases (CVDs) share common risk factors. However, the association between ACOS and the incidence of CVDs has not been reported. This study investigated the relationship between CVDs and ACOS in the general population. Setting Data were obtained from Taiwan's National Health Insurance Research Database for the period 2000 to 2010. Participants The ACOS cohort comprised patients (n= 5814) who had received a diagnosis of asthma and COPD. The non-ACOS cohort comprised patients who had not received a diagnosis of asthma or COPD and were matched to the ACOS cohort (2:1) by age, sex and index date (n= 11 625). Primary and secondary outcome measures The cumulative incidence of CVDs-coronary artery disease (CAD), cardiac dysrhythmia (CD) and heart failure (HF)-was calculated. Cox proportional regression analysis was employed to examine the relationship between ACOS and CVDs. Results After adjustment for multiple confounding factors-age, sex, comorbidities and medications-patients with ACOS were associated with a significantly higher risk of CVDs; the adjusted HRs (aHRs; 95% CI) for CAD, CD and HF were 1.62 (1.50 to 1.76), 1.44 (1.30 to 1.61) and 1.94 (1.73 to 2.19), respectively, whereas those of beta-blockers treatment for CAD, CD and HF were 1.19 (0.92 to 1.53), 0.90 (0.56 to 1.45) and 0.82 (0.49 to 1.38). The aHR of atenolol treatment for CD was 1.72 (1.01 to 2.93). The aHRs (95% CIs) of ACOS without acute exacerbation of COPD (AE-COPD) for CAD, CD and HF were 1.85 (1.70 to 2.01), 1.57 (1.40 to 1.77) and 2.07 (1.82 to 2.35), respectively. Conclusion ACOS was associated with higher CVD risk, even without the presence of previous comorbidities or AE-COPD. No significant differences in CVD events were observed in the ACOS cohort using beta-blockers, except for those using atenolol for treating CD. |
| 關聯: | BMJ Open, v.7, n.10, e017657 |
| 顯示於類別: | [嬰幼兒保育系] 期刊論文
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