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| 標題: | Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents |
| 作者: | Reddy, Mopur Vijaya Bhaskar
Hung, Hsin-Yi
Kuo, Ping-Chung
Huang, Guan-Jhong
Chan, Yu-Yi
Huang, Shiow-Chyn
Wu, Shwu-Jen
Morris-Natschke, Susan L.
Lee, Kuo-Hsiung
Wu, Tian-Shung |
| 貢獻者: | Natl Cheng Kung Univ,Natl Cheng Kung Univ Hosp, Coll Med, Sch Pharm
China Med Univ, Coll Pharm, Sch Chinese Pharmaceut Sci & Chinese Med Resource
South Taiwan Univ Sci & Technol, Dept Biotechnol
Chia Nan Univ Pharm & Sci, Grad Inst Pharmaceut Sci
Chung Hua Univ Med Technol, Dept Med Technol
Univ N Carolina, UNC Eshelman Sch Pharm, Nat Prod Res Labs
China Med Univ,China Med Univ Hosp, Chinese Med Res & Dev Ctr
Tajen Univ, Coll Pharm & Hlth Care, Dept Pharm |
| 關鍵字: | Chalcones
Dihydrochalcones
1,3-Diarylpropane analogs
Anti-inflammatory agents |
| 日期: | 2017-04-01 |
| 上傳時間: | 2018-11-30 15:49:48 (UTC+8) |
| 出版者: | Pergamon-Elsevier Science Ltd |
| 摘要: | Twenty-one chalcones were prepared via aldol condensation and subsequent reduction of these compound led to the corresponding dihydrochalcone and 1,3-diphenylpropane derivatives. The synthetic products were examined for their effects on NO inhibition in LPS-activated mouse peritoneal macrophages. Among the tested compounds, a 1,3-diarylpropane analog, 2-(3-(3,4-dimethoxyphenyl)propyl)5-methoxyphenol (3p), displayed the most significant inhibitory effects against NO production. To investigate the mechanism of action, the effects of 3p on iNOS and COX-2 protein expression were studied by immunoblot. The results concluded that 3p is capable of inhibiting iNOS expression in LPS-induced RAW264.7 cells via attenuation of NF-kappa B signaling by ERIC, p38, and JNK. (C) 2017 Elsevier Ltd. All rights reserved. |
| 關聯: | Bioorganic & Medicinal Chemistry Letters, v.27, n.7, pp.1547-1550 |
| 顯示於類別: | [化妝品應用與管理系(所)] 期刊論文
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