Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents

doi:10.1016/j.bmcl.2017.02.038

CNU IR > Pharmacy and Science > Dept. of Cosmetic Science and institute of cosmetic science > Periodical Articles > Item 310902800/31601

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/31601

Title:	Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents
Authors:	Reddy, Mopur Vijaya Bhaskar Hung, Hsin-Yi Kuo, Ping-Chung Huang, Guan-Jhong Chan, Yu-Yi Huang, Shiow-Chyn Wu, Shwu-Jen Morris-Natschke, Susan L. Lee, Kuo-Hsiung Wu, Tian-Shung
Contributors:	Natl Cheng Kung Univ,Natl Cheng Kung Univ Hosp, Coll Med, Sch Pharm China Med Univ, Coll Pharm, Sch Chinese Pharmaceut Sci & Chinese Med Resource South Taiwan Univ Sci & Technol, Dept Biotechnol Chia Nan Univ Pharm & Sci, Grad Inst Pharmaceut Sci Chung Hua Univ Med Technol, Dept Med Technol Univ N Carolina, UNC Eshelman Sch Pharm, Nat Prod Res Labs China Med Univ,China Med Univ Hosp, Chinese Med Res & Dev Ctr Tajen Univ, Coll Pharm & Hlth Care, Dept Pharm
Keywords:	Chalcones Dihydrochalcones 1,3-Diarylpropane analogs Anti-inflammatory agents
Date:	2017-04-01
Issue Date:	2018-11-30 15:49:48 (UTC+8)
Publisher:	Pergamon-Elsevier Science Ltd
Abstract:	Twenty-one chalcones were prepared via aldol condensation and subsequent reduction of these compound led to the corresponding dihydrochalcone and 1,3-diphenylpropane derivatives. The synthetic products were examined for their effects on NO inhibition in LPS-activated mouse peritoneal macrophages. Among the tested compounds, a 1,3-diarylpropane analog, 2-(3-(3,4-dimethoxyphenyl)propyl)5-methoxyphenol (3p), displayed the most significant inhibitory effects against NO production. To investigate the mechanism of action, the effects of 3p on iNOS and COX-2 protein expression were studied by immunoblot. The results concluded that 3p is capable of inhibiting iNOS expression in LPS-induced RAW264.7 cells via attenuation of NF-kappa B signaling by ERIC, p38, and JNK. (C) 2017 Elsevier Ltd. All rights reserved.
Relation:	Bioorganic & Medicinal Chemistry Letters, v.27, n.7, pp.1547-1550
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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