Glycyrrhizic acid increases glucagon like peptide-1 secretion via TGR5 activation in type 1-like diabetic rats

doi:10.1016/j.biopha.2017.08.087

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標題:	Glycyrrhizic acid increases glucagon like peptide-1 secretion via TGR5 activation in type 1-like diabetic rats
作者:	Wang, Lin-Yu Cheng, Kai Chun Li, Yingxiao Niu, Chiang-Shan Cheng, Juei-Tang Niu, Ho-Shan
貢獻者:	Chia Nan Univ Pharm & Sci, Dept Childhood Educ & Nursery Chi Mei Med Ctr, Div Pediat Kaohsiung Med Univ, Coll Med, Dept Med Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Psychosomat Internal Med Chi Mei Med Ctr, Dept Med Res Tzu Chi Univ Sci & Technol, Dept Nursing Chang Jung Christian Univ, Coll Hlth Sci, Inst Med Sci
關鍵字:	Glycyrrhizic acid GLP-1 TGR5 Triamterene Sitagliptin
日期:	2017-11
上傳時間:	2018-11-30 15:49:46 (UTC+8)
出版者:	Elsevier France-Editions Scientifiques Medicales Elsevier
摘要:	Glycyrrhizic acid (GA) is belonged to triterpenoid saponin that is contained in the root of licorice and is known to affect metabolic regulation. Recently, glucagon like peptide-1 (GLP-1) has widely been applied in diabetes therapeutics. However, the role of GLP-1 in GA-induced anti-diabetic effects is still unknown. Therefore, we are interested in understanding the association of GLP-1 with GA-induced effects. In type 1-like diabetic rats induced by streptozotocin (STZ-treated rats), GA increased the level of plasma GLP-1, which was blocked by triamterene at a dose sufficient to inhibit Takeda G-protein-coupled receptor 5 (TGR5). The direct effect of GA on TGR5 has been identified using the cultured Chinese hamster ovary cells (CHO-K1 cells) transfected TGR5 gene. Moreover, in intestinal NCI-H716 cells that secreted GLP-1, GA promoted GLP-1 secretion with a marked elevation of calcium levels. However, both effects of GA were reduced by ablation of TGR5 with siRNA in NCI-H716 cells. Therefore, we demonstrated that GA can enhance GLP-1 secretion through TGR5 activation.
關聯:	Biomedicine & Pharmacotherapy, v.95, pp.599-604
Appears in Collections:	[嬰幼兒保育系] 期刊論文

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