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| 標題: | Glycyrrhizic acid increases glucagon like peptide-1 secretion via TGR5 activation in type 1-like diabetic rats |
| 作者: | Wang, Lin-Yu
Cheng, Kai Chun
Li, Yingxiao
Niu, Chiang-Shan
Cheng, Juei-Tang
Niu, Ho-Shan |
| 貢獻者: | Chia Nan Univ Pharm & Sci, Dept Childhood Educ & Nursery
Chi Mei Med Ctr, Div Pediat
Kaohsiung Med Univ, Coll Med, Dept Med
Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Psychosomat Internal Med
Chi Mei Med Ctr, Dept Med Res
Tzu Chi Univ Sci & Technol, Dept Nursing
Chang Jung Christian Univ, Coll Hlth Sci, Inst Med Sci |
| 關鍵字: | Glycyrrhizic acid
GLP-1
TGR5
Triamterene
Sitagliptin |
| 日期: | 2017-11 |
| 上傳時間: | 2018-11-30 15:49:46 (UTC+8) |
| 出版者: | Elsevier France-Editions Scientifiques Medicales Elsevier |
| 摘要: | Glycyrrhizic acid (GA) is belonged to triterpenoid saponin that is contained in the root of licorice and is known to affect metabolic regulation. Recently, glucagon like peptide-1 (GLP-1) has widely been applied in diabetes therapeutics. However, the role of GLP-1 in GA-induced anti-diabetic effects is still unknown. Therefore, we are interested in understanding the association of GLP-1 with GA-induced effects. In type 1-like diabetic rats induced by streptozotocin (STZ-treated rats), GA increased the level of plasma GLP-1, which was blocked by triamterene at a dose sufficient to inhibit Takeda G-protein-coupled receptor 5 (TGR5). The direct effect of GA on TGR5 has been identified using the cultured Chinese hamster ovary cells (CHO-K1 cells) transfected TGR5 gene. Moreover, in intestinal NCI-H716 cells that secreted GLP-1, GA promoted GLP-1 secretion with a marked elevation of calcium levels. However, both effects of GA were reduced by ablation of TGR5 with siRNA in NCI-H716 cells. Therefore, we demonstrated that GA can enhance GLP-1 secretion through TGR5 activation. |
| 關聯: | Biomedicine & Pharmacotherapy, v.95, pp.599-604 |
| 顯示於類別: | [嬰幼兒保育系] 期刊論文
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