Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/31131
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    標題: Chemical constituents from termite-associated Xylaria acuminatilongissima YMJ623
    作者: Ting-Yu Cho (卓霆宇)
    Guei-Jane Wang (汪貴珍)
    Yu-Ming Ju (朱宇敏)
    Mei-Chuan Chen (陳美全)
    Tzong-Huei Lee (李宗徽)
    貢獻者: Graduate Institute of Pharmacognocy, Taipei Medical University
    Graduate Insitute of Clinical Medical Science, China Medical University
    Institute of Plant and Microbial Biology, Academia Sinica
    The Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs, Taipei medical University
    Institute of Fisheries Science, National Taiwan University
    日期: 2015-11-14
    上傳時間: 2018-03-27 09:33:59 (UTC+8)
    摘要: Three previously unreported benzofurans, namely acumifurans A-C (1–3), along with five known compounds, 2-(isopropyl-I'-ol)-2,3-dihydrobenzofuran-5-carbinol (4), fomannoxin alcohol (5), fomannoxin (6), acremine S (7) and cyclo(L-Pro-L-Leu) (8), were isolated from the ethyl acetate extracts of the fermented broths of termite associated Xylaria acuminatilongissima YMJ623. Compound 4, a synthetic benzofuran analogue, was isolated for the first time from natural resources. The structures of 1-8 were determined through spectroscopic data analysis. The absolute configurations of 1-4 were established based mainly on ROESY experiment and Mosher's reaction, and compared with the optical rotation data of the literatures. The effects of these compounds on the inhibition of NO production in lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cells were also evaluated. Of the compounds tested, 6 showed a mild NO production inhibitory activity without any cytotoxicity, and its average maximum inhibition (Emax) at 100 µM was 42.98±0.87%.
    關聯: 2015台灣藥學年會暨學術研討會，起迄日：2015/11/14，地點：嘉南藥理大學
    显示于类别:[藥理學院] 2015台灣藥學年會暨學術研討會

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