Chemical constituents from termite-associated Xylaria acuminatilongissima YMJ623

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Title:	Chemical constituents from termite-associated Xylaria acuminatilongissima YMJ623
Authors:	Ting-Yu Cho (卓霆宇) Guei-Jane Wang (汪貴珍) Yu-Ming Ju (朱宇敏) Mei-Chuan Chen (陳美全) Tzong-Huei Lee (李宗徽)
Contributors:	Graduate Institute of Pharmacognocy, Taipei Medical University Graduate Insitute of Clinical Medical Science, China Medical University Institute of Plant and Microbial Biology, Academia Sinica The Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs, Taipei medical University Institute of Fisheries Science, National Taiwan University
Date:	2015-11-14
Issue Date:	2018-03-27 09:33:59 (UTC+8)
Abstract:	Three previously unreported benzofurans, namely acumifurans A-C (1–3), along with five known compounds, 2-(isopropyl-I'-ol)-2,3-dihydrobenzofuran-5-carbinol (4), fomannoxin alcohol (5), fomannoxin (6), acremine S (7) and cyclo(L-Pro-L-Leu) (8), were isolated from the ethyl acetate extracts of the fermented broths of termite associated Xylaria acuminatilongissima YMJ623. Compound 4, a synthetic benzofuran analogue, was isolated for the first time from natural resources. The structures of 1-8 were determined through spectroscopic data analysis. The absolute configurations of 1-4 were established based mainly on ROESY experiment and Mosher's reaction, and compared with the optical rotation data of the literatures. The effects of these compounds on the inhibition of NO production in lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cells were also evaluated. Of the compounds tested, 6 showed a mild NO production inhibitory activity without any cytotoxicity, and its average maximum inhibition (Emax) at 100 µM was 42.98±0.87%.
Relation:	2015台灣藥學年會暨學術研討會，起迄日：2015/11/14，地點：嘉南藥理大學
Appears in Collections:	[Pharmacy and Science] 2015 Annual symposium of the pharmaceutical society of Taiwan

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