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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/31070


    標題: Reversine Induced Multinucleated Cells, Cell Apoptosis and Autophagy in Human Non-Small Cell Lung Cancer Cells
    作者: Lu, Yin-Che
    Lee, Ying-Ray
    Liao, Ji-Der
    Lin, Ching-Yen
    Chen, Yih-Yuan
    Chen, Ping-Tzu
    Tseng, Ya-Shih
    貢獻者: Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    Chia Yi Christian Hosp, Ditmanson Med Fdn, Div Hematol Oncol
    Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Med Res
    Chung Hwa Univ Med Technol, Coll Med & Life Sci, Dept Med Lab Sci & Biotechnol
    Natl Chiayi Univ, Dept Biochem Sci & Technol
    Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Internal Med
    關鍵字: aurora kinase
    antitumor-activity
    mitotic kinase
    overexpression
    resistance
    expression
    carcinoma
    amplification
    inhibitor
    erlotinib
    日期: 2016-07
    上傳時間: 2018-01-18 11:41:04 (UTC+8)
    出版者: Public Library Science
    摘要: Reversine, an A3 adenosine receptor antagonist, has been shown to induce differentiated myogenic-lineage committed cells to become multipotent mesenchymal progenitor cells. We and others have reported that reversine has an effect on human tumor suppression. This study revealed anti-tumor effects of reversine on proliferation, apoptosis and autophagy induction in human non-small cell lung cancer cells. Treatment of these cells with reversine suppressed cell growth in a time- and dosage-dependent manner. Moreover, polyploidy occurred after reversine treatment. In addition, caspase-dependent apoptosis and activation of autophagy by reversine in a dosage-dependent manner were also observed. We demonstrated in this study that reversine contributes to growth inhibition, apoptosis and autophagy induction in human lung cancer cells. Therefore, reversine used as a potential therapeutic agent for human lung cancer is worthy of further investigation.
    關聯: Plos One, v.11 n.7, e0158587
    Appears in Collections:[保健營養系(所) ] 期刊論文

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