Reversine Induced Multinucleated Cells, Cell Apoptosis and Autophagy in Human Non-Small Cell Lung Cancer Cells

doi:10.1371/journal.pone.0158587

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Title:	Reversine Induced Multinucleated Cells, Cell Apoptosis and Autophagy in Human Non-Small Cell Lung Cancer Cells
Authors:	Lu, Yin-Che Lee, Ying-Ray Liao, Ji-Der Lin, Ching-Yen Chen, Yih-Yuan Chen, Ping-Tzu Tseng, Ya-Shih
Contributors:	Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Chia Yi Christian Hosp, Ditmanson Med Fdn, Div Hematol Oncol Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Med Res Chung Hwa Univ Med Technol, Coll Med & Life Sci, Dept Med Lab Sci & Biotechnol Natl Chiayi Univ, Dept Biochem Sci & Technol Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Internal Med
Keywords:	aurora kinase antitumor-activity mitotic kinase overexpression resistance expression carcinoma amplification inhibitor erlotinib
Date:	2016-07
Issue Date:	2018-01-18 11:41:04 (UTC+8)
Publisher:	Public Library Science
Abstract:	Reversine, an A3 adenosine receptor antagonist, has been shown to induce differentiated myogenic-lineage committed cells to become multipotent mesenchymal progenitor cells. We and others have reported that reversine has an effect on human tumor suppression. This study revealed anti-tumor effects of reversine on proliferation, apoptosis and autophagy induction in human non-small cell lung cancer cells. Treatment of these cells with reversine suppressed cell growth in a time- and dosage-dependent manner. Moreover, polyploidy occurred after reversine treatment. In addition, caspase-dependent apoptosis and activation of autophagy by reversine in a dosage-dependent manner were also observed. We demonstrated in this study that reversine contributes to growth inhibition, apoptosis and autophagy induction in human lung cancer cells. Therefore, reversine used as a potential therapeutic agent for human lung cancer is worthy of further investigation.
Relation:	Plos One, v.11 n.7, e0158587
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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