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https://ir.cnu.edu.tw/handle/310902800/31063
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| 標題: | Effect of Systemic Lupus Erythematosus on the Risk of Incident Respiratory Failure: A National Cohort Study |
| 作者: | Yeh, Jun-Jun
Wang, Yu-Chiao
Chen, Jiunn-Horng
Hsu, Wu-Huei |
| 貢獻者: | Chia Yi Christian Hosp, Ditmanson Med Fdn
Chia Nan Univ Pharm & Sci
Meiho Univ
China Med Univ Hosp, Management Off Hlth Data
China Med Univ, Coll Med
China Med Univ, Coll Med, Grad Inst Clin Med Sci
China Med Univ Hosp, Dept Internal Med, Div Rheumatol
China Med Univ Hosp, Dept Internal Med, Div Pulm & Crit Care Med |
| 關鍵字: | of-death analysis
antiphospholipid syndrome
retrospective cohort
organ involvement
clinical-picture
ischemic-stroke
icd-9-cm codes
population
mortality
pneumonia |
| 日期: | 2016-09 |
| 上傳時間: | 2018-01-18 11:40:54 (UTC+8) |
| 出版者: | Public Library Science |
| 摘要: | Purpose We conducted a nationwide cohort study to investigate the relationship between systemic lupus erythematosus (SLE) and the risk of incident respiratory failure. Methods From the National Health Insurance Research Database, we identified 11 533 patients newly diagnosed with SLE and 46 132 controls without SLE who were randomly selected through frequency-matching according to age, sex, and index year. Both cohorts were followed until the end of 2011 to measure the incidence of incident respiratory failure, which was compared between the 2 cohorts through a Cox proportional hazards regression analysis. Results The adjusted hazard ratio (aHR) of incident respiratory failure was 5.80 (95% confidence interval [CI] = 5.15-6.52) for the SLE cohort after we adjusted for sex, age, and comorbidities. Both men (aHR = 3.44, 95% CI = 2.67-4.43) and women (aHR = 6.79, 95% CI = 5.93-7.77) had a significantly higher rate of incident respiratory failure in the SLE cohort than in the non-SLE cohort. Both men and women aged < 35 years (aHR = 31.2, 95% CI = 21.6-45.2), 35-65 years; (aHR = 6.19, 95% CI = 5.09-7.54) and >= 65 years (aHR = 2.35, 95% CI = 1.92-2.87) had a higher risk of incident respiratory failure in the SLE cohort. Moreover, the risk of incident respiratory failure was higher in the SLE cohort than the non-SLE cohort, for subjects with (aHR = 2.65, 95% CI = 2.22-3.15) or without (aHR = 9.08, 95% CI = 7.72-10.7) pre-existing comorbidities. In the SLE cohort, subjects with >24 outpatient visits and hospitalizations per year had a higher incident respiratory failure risk (aHR = 21.7, 95% CI = 18.0-26.1) compared with the non-SLE cohort. Conclusion Patients with SLE are associated with an increased risk of incident respiratory failure, regardless of their age, sex, and pre-existing comorbidities; especially medical services with higher frequency. |
| 關聯: | Plos One, v.11 n.9, e0163382 |
| 顯示於類別: | [嬰幼兒保育系] 期刊論文
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