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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/31055


    標題: Antinociceptive and Anti-Inflammatory Effects of Zerumbone against Mono-Iodoacetate-Induced Arthritis
    作者: Chien, Ting-Yi
    Huang, Steven Kuan-Hua
    Lee, Chia-Jung
    Tsai, Po-Wei
    Wang, Ching-Chiung
    貢獻者: Shih Chien Univ, Dept Food Sci Nutr & Nutraceut Biotechnol
    Taipei Med Univ, Coll Pharm, Sch Pharm
    Chi Mei Med Ctr, Dept Surg, Div Urooncol
    Chia Nan Univ Pharm & Sci, Dept Appl Life Sci & Hlth
    Taipei Med Univ, PhD Program Clin Drug Discovery Chinese Herbal Me, Coll Pharm
    Taipei Med Univ Hosp, Orthoped Res Ctr
    關鍵字: Zingiber zerumbet Smith
    zerumbone
    arthritis
    anti-inflammatory
    heme oxygenase-1
    metalloproteinase
    日期: 2016-02
    上傳時間: 2018-01-18 11:40:43 (UTC+8)
    出版者: Mdpi Ag
    摘要: The fresh rhizome of Zingiber zerumbet Smith (Zingiberaceae) is used as a food flavoring and also serves as a folk medicine as an antipyretic and for analgesics in Taiwan. Zerumbone, a monocyclic sesquiterpene was isolated from the rhizome of Z. zerumbet and is the major active compound. In this study, the anti-inflammatory and antinociceptive effects of zerumbone on arthritis were explored using in vitro and in vivo models. Results showed that zerumbone inhibited inducible nitric oxide (NO) synthase (iNOS), cyclooxygenase (COX)-2 expressions, and NO and prostaglandin E-2 (PGE(2)) production, but induced heme oxygenase (HO)-1 expression in a dose-dependent manner in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. When zerumbone was co-treated with an HO-1 inhibitor (tin protoporphyrin (SnPP)), the NO inhibitory effects of zerumbone were recovered. The above results suggest that zerumbone inhibited iNOS and COX-2 through induction of the HO-1 pathway. Moreover, matrix metalloproteinase (MMP)-13 and COX-2 expressions of interleukin (IL)-1-stimulated primary rat chondrocytes were inhibited by zerumbone. In an in vivo assay, an acetic acid-induced writhing response in mice was significantly reduced by treatment with zerumbone. Furthermore, zerumbone reduced paw edema and the pain response in a mono-iodoacetate (MIA)-induced rat osteoarthritis model. Therefore, we suggest that zerumbone possesses anti-inflammatory and antinociceptive effects which indicate zerumbone could be a potential candidate for osteoarthritis treatment.
    關聯: International Journal of Molecular Sciences, v.17 n.2, 249
    Appears in Collections:[生活應用與保健系] 期刊論文

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