Antinociceptive and Anti-Inflammatory Effects of Zerumbone against Mono-Iodoacetate-Induced Arthritis

doi:10.3390/ijms17020249

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Title:	Antinociceptive and Anti-Inflammatory Effects of Zerumbone against Mono-Iodoacetate-Induced Arthritis
Authors:	Chien, Ting-Yi Huang, Steven Kuan-Hua Lee, Chia-Jung Tsai, Po-Wei Wang, Ching-Chiung
Contributors:	Shih Chien Univ, Dept Food Sci Nutr & Nutraceut Biotechnol Taipei Med Univ, Coll Pharm, Sch Pharm Chi Mei Med Ctr, Dept Surg, Div Urooncol Chia Nan Univ Pharm & Sci, Dept Appl Life Sci & Hlth Taipei Med Univ, PhD Program Clin Drug Discovery Chinese Herbal Me, Coll Pharm Taipei Med Univ Hosp, Orthoped Res Ctr
Keywords:	Zingiber zerumbet Smith zerumbone arthritis anti-inflammatory heme oxygenase-1 metalloproteinase
Date:	2016-02
Issue Date:	2018-01-18 11:40:43 (UTC+8)
Publisher:	Mdpi Ag
Abstract:	The fresh rhizome of Zingiber zerumbet Smith (Zingiberaceae) is used as a food flavoring and also serves as a folk medicine as an antipyretic and for analgesics in Taiwan. Zerumbone, a monocyclic sesquiterpene was isolated from the rhizome of Z. zerumbet and is the major active compound. In this study, the anti-inflammatory and antinociceptive effects of zerumbone on arthritis were explored using in vitro and in vivo models. Results showed that zerumbone inhibited inducible nitric oxide (NO) synthase (iNOS), cyclooxygenase (COX)-2 expressions, and NO and prostaglandin E-2 (PGE(2)) production, but induced heme oxygenase (HO)-1 expression in a dose-dependent manner in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. When zerumbone was co-treated with an HO-1 inhibitor (tin protoporphyrin (SnPP)), the NO inhibitory effects of zerumbone were recovered. The above results suggest that zerumbone inhibited iNOS and COX-2 through induction of the HO-1 pathway. Moreover, matrix metalloproteinase (MMP)-13 and COX-2 expressions of interleukin (IL)-1-stimulated primary rat chondrocytes were inhibited by zerumbone. In an in vivo assay, an acetic acid-induced writhing response in mice was significantly reduced by treatment with zerumbone. Furthermore, zerumbone reduced paw edema and the pain response in a mono-iodoacetate (MIA)-induced rat osteoarthritis model. Therefore, we suggest that zerumbone possesses anti-inflammatory and antinociceptive effects which indicate zerumbone could be a potential candidate for osteoarthritis treatment.
Relation:	International Journal of Molecular Sciences, v.17 n.2, 249
Appears in Collections:	[Dept. of Life and Health Science] Periodical Articles

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