Morphology and opto-thermal properties of the thermo-responsive PNIPAAm-protected gold nanorods

doi:10.1016/j.polymer.2015.12.047

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 化妝品應用與管理系(所) > 期刊論文 > Item 310902800/31033

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標題:	Morphology and opto-thermal properties of the thermo-responsive PNIPAAm-protected gold nanorods
作者:	Lee, Chia-Fen Zhang, Geng-Ming Nieh, Mu-Ping Don, Trong-Ming
貢獻者:	Chia Nan Univ Pharm & Sci, Inst Cosmet Sci, Dept Cosmet Sci Tamkang Univ, Dept Chem & Mat Engn Univ Connecticut, Inst Mat Sci, Polymer Program
關鍵字:	poly(N-isopropyl acrylamide) Gold nanorods Thermo-responsive Opto-thermal effect delivery
日期:	2016-02
上傳時間:	2018-01-18 11:40:16 (UTC+8)
出版者:	Elsevier Sci Ltd
摘要:	In this study, thermo-responsive poly(N-isopropyl acrylamide)-g-gold nanorods (PNIPAAm-g-GNRs) were prepared by grafting telechelic PNIPAAm-SH to the GNRs. They were stable in aqueous medium where the GNRs were protected by PNIPAAm chains as revealed by transmission electron microscope. The longitudinal surface plasmon absorbance had a red shift to 810 nm, and the lower critical solution temperature (LCST) of the PNIPAAm was increased to 34.9 degrees C. After being irradiated by near-IR for 5 min, the PNIPAAm-g-GNRs solution indicated a temperature increment above its LCST. The opto-thermal effect thus could induce the morphology change of the PNIPAAm, which was found to be reversible. Furthermore, the PNIPAAm-g-GNRs had a much lower cytotoxicity than the surfactant-stabilized GNRs. The cell viability of fibroblast after two days of culture could still reach 89.0% relative to the control. Therefore, the PNIPAAm-g-GNRs could be used as drug carriers in which the drug-release could be controlled by remote near-IR. (C) 2015 Elsevier Ltd. All rights reserved.
關聯:	Polymer, v.84, pp.138-147
显示于类别:	[化妝品應用與管理系(所)] 期刊論文

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