Loading...
|
Please use this identifier to cite or link to this item:
https://ir.cnu.edu.tw/handle/310902800/31033
|
| Title: | Morphology and opto-thermal properties of the thermo-responsive PNIPAAm-protected gold nanorods |
| Authors: | Lee, Chia-Fen
Zhang, Geng-Ming
Nieh, Mu-Ping
Don, Trong-Ming |
| Contributors: | Chia Nan Univ Pharm & Sci, Inst Cosmet Sci, Dept Cosmet Sci
Tamkang Univ, Dept Chem & Mat Engn
Univ Connecticut, Inst Mat Sci, Polymer Program |
| Keywords: | poly(N-isopropyl acrylamide)
Gold nanorods
Thermo-responsive
Opto-thermal effect
delivery |
| Date: | 2016-02 |
| Issue Date: | 2018-01-18 11:40:16 (UTC+8) |
| Publisher: | Elsevier Sci Ltd |
| Abstract: | In this study, thermo-responsive poly(N-isopropyl acrylamide)-g-gold nanorods (PNIPAAm-g-GNRs) were prepared by grafting telechelic PNIPAAm-SH to the GNRs. They were stable in aqueous medium where the GNRs were protected by PNIPAAm chains as revealed by transmission electron microscope. The longitudinal surface plasmon absorbance had a red shift to 810 nm, and the lower critical solution temperature (LCST) of the PNIPAAm was increased to 34.9 degrees C. After being irradiated by near-IR for 5 min, the PNIPAAm-g-GNRs solution indicated a temperature increment above its LCST. The opto-thermal effect thus could induce the morphology change of the PNIPAAm, which was found to be reversible. Furthermore, the PNIPAAm-g-GNRs had a much lower cytotoxicity than the surfactant-stabilized GNRs. The cell viability of fibroblast after two days of culture could still reach 89.0% relative to the control. Therefore, the PNIPAAm-g-GNRs could be used as drug carriers in which the drug-release could be controlled by remote near-IR. (C) 2015 Elsevier Ltd. All rights reserved. |
| Relation: | Polymer, v.84, pp.138-147 |
| Appears in Collections: | [Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles
|
Files in This Item:
| File |
Description |
Size | Format | |
|---|
| 31033.pdf | | 2083Kb | Adobe PDF | 583 | View/Open | | index.html | | 0Kb | HTML | 1409 | View/Open |
|
All items in CNU IR are protected by copyright, with all rights reserved.
|
