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| 標題: | Curcumin analog L3 alleviates diabetic atherosclerosis by multiple effects |
| 作者: | Zheng, Bin
Yang, Liu
Wen, Caixia
Huang, Xiuwang
Xu, Chenxia
Lee, Kuan-Han
Xu, Jianhua |
| 貢獻者: | Fujian Med Univ, Sch Pharm, Dept Pharmacol
Fuijan Prov Key Lab Nat Med Pharmacol
Fujian Med Univ, Union Hosp, Dept Pharm
Fujian Med Univ, Sch Pharm, Dept Med Chem
Chia Nan Univ Pharm & Sci, Sch Pharm |
| 關鍵字: | L3
Analog of curcumin
Diabetic atherosclerosis
Dyslipidemia
Hyperglycemia |
| 日期: | 2016-03 |
| 上傳時間: | 2018-01-18 11:40:01 (UTC+8) |
| 出版者: | Elsevier Science Bv |
| 摘要: | L3, an analog of curcumin, is a compound isolated from a traditional Chinese medicine Turmeric. In this paper, we aims to explore the efficacy of L3 on diabetic atherosclerosis and the related mechanism. The effect of L3 was studied on glucose and lipid metabolism, antioxidant status, atherosclerosis-related indexes and pathological changes of main organs in the mice model of diabetes induced by streptozotocin and high-fat diet. The results showed that L3 treatment could meliorate dyslipidemia and hyperglycemia, reduce oxidative stress, enhance the activity of antioxidases, increase the nitric oxide level in plasma and aortic arch, decrease the production of reactive oxygen species in pancreas and lectin-like oxidized low-density lipoprotein receptor-1 expression in aortic arch, and meliorate the fatty and atherosclerotic degeneration in aortic arch, thereby preventing the development of diabetes and its complications. These results suggested that L3 can alleviate the diabetic atherosclerosis by multiple effects. This study provided scientific basis for the further research and clinical application of L3. (C) 2016 Elsevier B.V. All rights reserved. |
| 關聯: | European Journal of Pharmacology, v.775, pp.22-34 |
| 顯示於類別: | [藥學系(所)] 期刊論文
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