Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/31022
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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/31022


    Title: Curcumin analog L3 alleviates diabetic atherosclerosis by multiple effects
    Authors: Zheng, Bin
    Yang, Liu
    Wen, Caixia
    Huang, Xiuwang
    Xu, Chenxia
    Lee, Kuan-Han
    Xu, Jianhua
    Contributors: Fujian Med Univ, Sch Pharm, Dept Pharmacol
    Fuijan Prov Key Lab Nat Med Pharmacol
    Fujian Med Univ, Union Hosp, Dept Pharm
    Fujian Med Univ, Sch Pharm, Dept Med Chem
    Chia Nan Univ Pharm & Sci, Sch Pharm
    Keywords: L3
    Analog of curcumin
    Diabetic atherosclerosis
    Dyslipidemia
    Hyperglycemia
    Date: 2016-03
    Issue Date: 2018-01-18 11:40:01 (UTC+8)
    Publisher: Elsevier Science Bv
    Abstract: L3, an analog of curcumin, is a compound isolated from a traditional Chinese medicine Turmeric. In this paper, we aims to explore the efficacy of L3 on diabetic atherosclerosis and the related mechanism. The effect of L3 was studied on glucose and lipid metabolism, antioxidant status, atherosclerosis-related indexes and pathological changes of main organs in the mice model of diabetes induced by streptozotocin and high-fat diet. The results showed that L3 treatment could meliorate dyslipidemia and hyperglycemia, reduce oxidative stress, enhance the activity of antioxidases, increase the nitric oxide level in plasma and aortic arch, decrease the production of reactive oxygen species in pancreas and lectin-like oxidized low-density lipoprotein receptor-1 expression in aortic arch, and meliorate the fatty and atherosclerotic degeneration in aortic arch, thereby preventing the development of diabetes and its complications. These results suggested that L3 can alleviate the diabetic atherosclerosis by multiple effects. This study provided scientific basis for the further research and clinical application of L3. (C) 2016 Elsevier B.V. All rights reserved.
    Relation: European Journal of Pharmacology, v.775, pp.22-34
    Appears in Collections:[Dept. of Pharmacy] Periodical Articles

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