Multi-Strain Probiotics Inhibit Cardiac Myopathies and Autophagy to Prevent Heart Injury in High-Fat Diet-Fed Rats

doi:10.7150/ijms.14769

Chia Nan University of Pharmacy & Science Institutional Repository > 智慧生活學院 > 醫務管理系(所) > 期刊論文 > Item 310902800/31013

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標題:	Multi-Strain Probiotics Inhibit Cardiac Myopathies and Autophagy to Prevent Heart Injury in High-Fat Diet-Fed Rats
作者:	Lai, Chao-Hung Tsai, Cheng-Chih Kuo, Wei-Wen Ho, Tsung-Jung Day, Cecilia-Hsuan Pai, Pei-ying Chung, Li-Chin Huang, Chun-Chih Wang, Hsueh-Fang Liao, Po-Hsiang Huang, Chih-Yang
貢獻者:	Armed Force Taichung Gen Hosp, Div Cardiol, Dept Internal Med HungKuang Univ, Dept Food Sci & Technol China Med Univ, Dept Biol Sci & Technol China Med Univ, Grad Inst Chinese Med Sci China Med Univ Beijing Hosp, Chinese Med Dept Meiho Univ, Dept Nursing China Med Univ Hosp, Div Cardiol Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm New Bellus Enterprises Co Ltd Hungkuang Univ, Inst Biomed Nutr China Med Univ, Grad Inst Basic Med Sci Asia Univ, Dept Hlth & Nutr Biotechnol
關鍵字:	High-fat diet Obesity probiotics Autophagy pathway
日期:	2016
上傳時間:	2018-01-18 11:39:50 (UTC+8)
出版者:	Ivyspring Int Publ
摘要:	High-fat diets induce obesity, leading to cardiomyocyte fibrosis and autophagy imbalance. In addition, no previous studies have indicated that probiotics have potential health effects associated with cardiac fibrosis and autophagy in obese rats. This study investigates the effects of probiotics on high-fat (HF) diet-induced obesity and cardiac fibrosis and autophagy in rat hearts. Eight-week-old male Wistar rats were separated randomly into five equally sized experimental groups: Normal diet (control) and high-fat (HF) diet groups and groups fed a high-fat diet supplemented with low (HL), medium (HM) or high (HH) doses of multi-strain probiotic powders. These experiments were designed for an 8-week trial period. The myocardial architecture of the left ventricle was evaluated using Masson's trichrome staining and immunohistochemistry staining. Key probiotics-related pathway molecules were analyzed using western blotting. Abnormal myocardial architecture and enlarged interstitial spaces were observed in HF hearts. These interstitial spaces were significantly decreased in groups provided with multi-strain probiotics compared with HF hearts. Western blot analysis demonstrated that key components of the TGF/MMP2/MMP9 fibrosis pathways and ERK5/uPA/ANP cardiac hypertrophy pathways were significantly suppressed in probiotic groups compared to the HF group. Autophagy balance is very important in cardiomyocytes. In this study, we observed that the beclin-1/LC3B/Atg7 autophagy pathway in HF was increased after probiotic supplementation was significantly decreased. Together, these results suggest that oral administration of probiotics may attenuate cardiomyocyte fibrosis and cardiac hypertrophy and the autophagy-signaling pathway in obese rats.
關聯:	International Journal of Medical Sciences, v.13 n.4, pp.277-285
顯示於類別:	[醫務管理系(所)] 期刊論文

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