Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/31013
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    標題: Multi-Strain Probiotics Inhibit Cardiac Myopathies and Autophagy to Prevent Heart Injury in High-Fat Diet-Fed Rats
    作者: Lai, Chao-Hung
    Tsai, Cheng-Chih
    Kuo, Wei-Wen
    Ho, Tsung-Jung
    Day, Cecilia-Hsuan
    Pai, Pei-ying
    Chung, Li-Chin
    Huang, Chun-Chih
    Wang, Hsueh-Fang
    Liao, Po-Hsiang
    Huang, Chih-Yang
    貢獻者: Armed Force Taichung Gen Hosp, Div Cardiol, Dept Internal Med
    HungKuang Univ, Dept Food Sci & Technol
    China Med Univ, Dept Biol Sci & Technol
    China Med Univ, Grad Inst Chinese Med Sci
    China Med Univ Beijing Hosp, Chinese Med Dept
    Meiho Univ, Dept Nursing
    China Med Univ Hosp, Div Cardiol
    Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
    New Bellus Enterprises Co Ltd
    Hungkuang Univ, Inst Biomed Nutr
    China Med Univ, Grad Inst Basic Med Sci
    Asia Univ, Dept Hlth & Nutr Biotechnol
    關鍵字: High-fat diet
    Obesity
    probiotics
    Autophagy
    pathway
    日期: 2016
    上傳時間: 2018-01-18 11:39:50 (UTC+8)
    出版者: Ivyspring Int Publ
    摘要: High-fat diets induce obesity, leading to cardiomyocyte fibrosis and autophagy imbalance. In addition, no previous studies have indicated that probiotics have potential health effects associated with cardiac fibrosis and autophagy in obese rats. This study investigates the effects of probiotics on high-fat (HF) diet-induced obesity and cardiac fibrosis and autophagy in rat hearts. Eight-week-old male Wistar rats were separated randomly into five equally sized experimental groups: Normal diet (control) and high-fat (HF) diet groups and groups fed a high-fat diet supplemented with low (HL), medium (HM) or high (HH) doses of multi-strain probiotic powders. These experiments were designed for an 8-week trial period. The myocardial architecture of the left ventricle was evaluated using Masson's trichrome staining and immunohistochemistry staining. Key probiotics-related pathway molecules were analyzed using western blotting. Abnormal myocardial architecture and enlarged interstitial spaces were observed in HF hearts. These interstitial spaces were significantly decreased in groups provided with multi-strain probiotics compared with HF hearts. Western blot analysis demonstrated that key components of the TGF/MMP2/MMP9 fibrosis pathways and ERK5/uPA/ANP cardiac hypertrophy pathways were significantly suppressed in probiotic groups compared to the HF group. Autophagy balance is very important in cardiomyocytes. In this study, we observed that the beclin-1/LC3B/Atg7 autophagy pathway in HF was increased after probiotic supplementation was significantly decreased. Together, these results suggest that oral administration of probiotics may attenuate cardiomyocyte fibrosis and cardiac hypertrophy and the autophagy-signaling pathway in obese rats.
    關聯: International Journal of Medical Sciences, v.13 n.4, pp.277-285
    显示于类别:[醫務管理系(所)] 期刊論文

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