Lactobacillus pentosus strain LPS16 produces lactic acid, inhibiting multidrug-resistant Helicobacter pylori

doi:10.1016/j.jmii.2014.04.014

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標題:	Lactobacillus pentosus strain LPS16 produces lactic acid, inhibiting multidrug-resistant Helicobacter pylori
作者:	Zheng, Po-Xing Fang, Hsin-Yi Yang, Hsiao-Bai Tien, Nai-Yueh Wang, Ming-Cheng Wu, Jiunn-Jong
貢獻者:	Natl Cheng Kung Univ, Coll Med, Inst Basic Med Sci Chia Nan Univ Pharm & Sci, Coll Pharm & Sci, Dept Biotechnol Ton Yen Gen Hosp, Dept Pathol Natl Cheng Kung Univ, Coll Med, Clin Pharm & Pharmaceut Sci Natl Cheng Kung Univ Hosp, Dept Internal Med Natl Cheng Kung Univ, Coll Med, Dept Med Lab Sci & Biotechnol Natl Cheng Kung Univ, Ctr Infect Dis & Signal Res
關鍵字:	Acid Bactericidal Helicobacter Lactobacillus mice
日期:	2016-04
上傳時間:	2018-01-18 11:38:18 (UTC+8)
出版者:	Elsevier Taiwan
摘要:	Background/Purpose: Helicobacter pylori is a human gastric pathogen. Antibiotic resistance of H. pylori has become a problem increasing the failure of H. pylori eradication. Therefore alternative approaches are required. The aim of this study was to evaluate the anti -H. pylori activity of Lactobacillus pentosus strain LPS16 and the mechanism of its killing effect. Methods: The anti -H. pylori activity of LPS16 was determined by the disc diffusion test and time killing assay. High-performance liquid chromatography analysis was used to analyze the secreted compounds of LPS16. Sixty H. pylori strains isolated from different gastric diseases, having different antibiotic susceptibility were collected to analyze the spectrum of anti -H. pylori activity of LPS16. Adhesion ability of LPS16 to gastric epithelial cell lines was assayed by flow cytometry. Results: The anti -H. pylori activity of LPS16 depended on the secreted component, and lactic acid mediated bactericidal activity against H. pylori. The bactericidal activity did not vary significantly among the strains isolated from different diseases having different antibiotic susceptibility. Moreover, LPS16 can adhere on gastric epithelial cell lines AKG and MKN45. Conclusion: L. pentosus strain LPS16 had the broad-spectrum anti -H. pylon activity, suggesting that it can be used to prevent H. pylon infection. Copyright (C) 2014, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. All rights reserved.
關聯:	Journal of Microbiology Immunology and Infection, v.49 n.2, pp.168-174
显示于类别:	[生物科技系(所)] 期刊論文

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