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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/30929

    標題: Patients with urothelial carcinoma have poor renal outcome regardless of whether they receive nephrouretectomy
    作者: Hung, Peir-Haur
    Tsai, Hung-Bin
    Hung, Kuan-Yu
    Muo, Chih-Hsin
    Chung, Mu-Chi
    Chang, Chao-Hsiang
    Chung, Chi-Jung
    貢獻者: Chiayi Christian Hosp, Dept Internal Med, Ditmanson Med Fdn
    Chia Nan Univ Pharm & Sci, Dept Appl Life Sci & Hlth
    Natl Taiwan Univ Hosp, Dept Tramatol
    Natl Taiwan Univ Hosp, Dept Internal Med, Hsin Chu Branch
    China Med Univ & Hosp, Management Off Hlth Data
    Taichung Vet Gen Hosp, Div Nephrol, Dept Med
    China Med Univ & Hosp, Dept Urol
    China Med Univ, Dept Hlth Risk Management, Coll Publ Hlth
    China Med Univ Hosp, Dept Med Res
    關鍵字: chronic kidney disease
    end stage renal disease
    urothelial carcinoma
    日期: 2016-09
    上傳時間: 2018-01-18 11:38:08 (UTC+8)
    出版者: Impact Journals Llc
    摘要: The association between urothelial carcinoma (UC) and subsequent ESRD incidence has not been confirmed. This was a population-based study using claims data from the Taiwan National Health Institutes from 1998 to 2010. The study cohort consisted of 26,017 patients with newly diagnosed UC and no history of ESRD, and the comparison cohort consisted of 208,136 matched enrollees without UC. The incidence of ESRD was ascertained through cross-referencing with a registry for catastrophic illnesses. Cox proportional hazard regression analysis was used to estimate the risk of ESRD associated with UC and UC subtype. A total of 979 patients (3.76%) from the UC group and 1,829 (0.88%) from the comparison group developed ESRD. Multivariable analysis indicated that compared with the comparison group, the hazard ratios (HRs) for ESRD were 7.75 (95% confidence interval [CI]: 6.84 to 8.78) and 3.12 (95% CI: 6.84 to 8.78) in the cohort with upper urinary tract UC (UT-UC) and bladder UC (B-UC), respectively. In addition, there were significantly increased risks for ESRD in UC patients receiving and not receiving nephrouretectomies or aristolochic acids (AA). Moreover, the UC patients receiving segmental ureterectomy and ureteral reimplantation had approximately 1.3-fold and 2.4-fold increased risk for ESRD after control for confounders, respectively. Thus, our data indicate that UT-UC and B-UC independently increased the risk for ESRD in patients after considering about nephrouretectomies or aristolochic acids (AA). In addition, UC patients receiving segmental ureterectomy and ureteral reimplantation had increased risk for ESRD.
    關聯: Oncotarget, v.7 n.38, pp.61679-61689
    Appears in Collections:[生活應用與保健系] 期刊論文

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