Patients with urothelial carcinoma have poor renal outcome regardless of whether they receive nephrouretectomy

doi:10.18632/oncotarget.11223

Chia Nan University of Pharmacy & Science Institutional Repository > 智慧生活學院 > 生活保健科技系 > 期刊論文 > Item 310902800/30929

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標題:	Patients with urothelial carcinoma have poor renal outcome regardless of whether they receive nephrouretectomy
作者:	Hung, Peir-Haur Tsai, Hung-Bin Hung, Kuan-Yu Muo, Chih-Hsin Chung, Mu-Chi Chang, Chao-Hsiang Chung, Chi-Jung
貢獻者:	Chiayi Christian Hosp, Dept Internal Med, Ditmanson Med Fdn Chia Nan Univ Pharm & Sci, Dept Appl Life Sci & Hlth Natl Taiwan Univ Hosp, Dept Tramatol Natl Taiwan Univ Hosp, Dept Internal Med, Hsin Chu Branch China Med Univ & Hosp, Management Off Hlth Data Taichung Vet Gen Hosp, Div Nephrol, Dept Med China Med Univ & Hosp, Dept Urol China Med Univ, Dept Hlth Risk Management, Coll Publ Hlth China Med Univ Hosp, Dept Med Res
關鍵字:	chronic kidney disease end stage renal disease nephrouretectomy urothelial carcinoma dialysis
日期:	2016-09
上傳時間:	2018-01-18 11:38:08 (UTC+8)
出版者:	Impact Journals Llc
摘要:	The association between urothelial carcinoma (UC) and subsequent ESRD incidence has not been confirmed. This was a population-based study using claims data from the Taiwan National Health Institutes from 1998 to 2010. The study cohort consisted of 26,017 patients with newly diagnosed UC and no history of ESRD, and the comparison cohort consisted of 208,136 matched enrollees without UC. The incidence of ESRD was ascertained through cross-referencing with a registry for catastrophic illnesses. Cox proportional hazard regression analysis was used to estimate the risk of ESRD associated with UC and UC subtype. A total of 979 patients (3.76%) from the UC group and 1,829 (0.88%) from the comparison group developed ESRD. Multivariable analysis indicated that compared with the comparison group, the hazard ratios (HRs) for ESRD were 7.75 (95% confidence interval [CI]: 6.84 to 8.78) and 3.12 (95% CI: 6.84 to 8.78) in the cohort with upper urinary tract UC (UT-UC) and bladder UC (B-UC), respectively. In addition, there were significantly increased risks for ESRD in UC patients receiving and not receiving nephrouretectomies or aristolochic acids (AA). Moreover, the UC patients receiving segmental ureterectomy and ureteral reimplantation had approximately 1.3-fold and 2.4-fold increased risk for ESRD after control for confounders, respectively. Thus, our data indicate that UT-UC and B-UC independently increased the risk for ESRD in patients after considering about nephrouretectomies or aristolochic acids (AA). In addition, UC patients receiving segmental ureterectomy and ureteral reimplantation had increased risk for ESRD.
關聯:	Oncotarget, v.7 n.38, pp.61679-61689
显示于类别:	[生活保健科技系] 期刊論文

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