R-polyglutamic acid / Carboxymethyl Cellulose / Aspirin / Calcium chloride藥物顆粒釋放行為之研究

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標題:	R-polyglutamic acid / Carboxymethyl Cellulose / Aspirin / Calcium chloride藥物顆粒釋放行為之研究 Preparation of R-polyglutamic acid / Carboxymethyl Cellulose / Aspirin / Calcium chloride on Drug Release Controlled Behavior
作者:	林以評
貢獻者:	藥學系林彰泰
關鍵字:	聚電解液複合物聚麩胺酸羧甲基纖維素藥物控制釋放 PGA CMC PEC Drug release controlled
日期:	2017
上傳時間:	2018-01-11 11:44:27 (UTC+8)
摘要:	本研究是將不同比例的阿斯匹靈Aspirin / 羧甲基纖維素CMC /聚麩胺酸PGA 溶液加入不同比例的氯化鈣溶液中，Ca2+離子分別與 CMC、PGA 上的羧基反應，形成交聯網狀結構。不同比例的高分子決定顆粒的物性，如粒徑大小、比表面積、藥物包埋率，並影響藥物的釋放的情況。 Nowadays the factory all over the world are face with the difficult to invent the new drug, except develop biopharmaceutical otherwise , make the old drug with new medicament to achieve the better curative. Human take medicine into body, after digestion the drug potency in blood have to maintain in effective concentration, if the drug concentration is too height, it will have secondary action. If the drug concentration is too low, it will do not have the drug effect. So that a good medicament have the advantage that release drug rate slowly and release drug with long time , use the minimum drug to achieve the best effect. This experiment is purpose to make medicament with carboxyl methyl cellulose and r-polymer glutamic acid.
關聯:	電子全文公開日期：2022-08-07，學年度：105，59頁
顯示於類別:	[藥學系(所)] 博碩士論文

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