Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/30510
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 17776/20117 (88%)
造访人次 : 10918111      在线人数 : 518
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    標題: Interactions between U-937 human macrophages and tyloxapol
    作者: Jo-wen Tseng(曾若雯)
    Jung-hua Steven Kuo(郭榮華)
    貢獻者: Graduate lnstitute of Pharmaceutical Science, Chia Nan University of Pharmacy and Science
    日期: 2008-07
    上傳時間: 2017-12-04 15:59:12 (UTC+8)
    摘要: Tyloxapol is reported to prevent macrophages from reacting to endotoxin. However, the intracellular responses that tyloxapol induces in macrophages are still not fully explored. Hence, the objective of this study was to evaluate the intracellular events in macrophages treated with tyloxapol and assess the antioxidant properties of tyloxapolin endotoxin-activated macrophages. Using flow cytometry, we examined intracellular responses in macrophages: reactive oxygen species (ROS) content, mitochondria membrane potential, and cell cycle profiles. We also assessed the antioxidant properties of tyloxapol in endotoxin-activated macrophages. Kinetic hydrogen peroxide production tended to decline with increasing doses. Tyloxapol produced a progressive increase followed by a decline in superoxide anion production in macrophages with increasing doses. Tyloxapol also caused unstable fluctuations in mitochondrial membrane potential. Apoptosis had developed at higher doses after 4h of incubation time. After 2 h of tyloxapol-pretreatment, tyloxapol acted as an antioxidant only at lower doses. Most tyloxapol-pretreated cells at lower doses fully recovered from the changes in superoxide anion and hydrogen peroxide production. Our findings contribute to a better understanding of the molecular action of tyloxapol in macrophages and how it protects macrophages against endotoxin.
    關聯: 第五屆海峽化學、生物及材料研討會,起迄日:2008/07/21-2008/07/22,地點:嘉南藥理科技大學
    显示于类别:[藥學系(所)] 會議論文
    [藥理學院] 2008第五屆海峽化學、生物及材料研討會


    档案 描述 大小格式浏览次数
    B08.pdf337KbAdobe PDF131检视/开启

    在CNU IR中所有的数据项都受到原著作权保护.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈