Preparation of Polypeptide via Living Polymerization of Z-Lys-NCA Initiated by Platinum Complexes

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 2008第五屆海峽化學、生物及材料研討會 > Item 310902800/30484

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標題:	Preparation of Polypeptide via Living Polymerization of Z-Lys-NCA Initiated by Platinum Complexes
作者:	Ya-Liu Peng Shu-Ling Lai Chu-Chieh Lin
貢獻者:	Department of Chemistry, National Chung Hsing University College of Design, Ling Tung University
日期:	2008-07
上傳時間:	2017-12-04 15:53:59 (UTC+8)
摘要:	Two novel platinum complexes, ((dppe)Pt(MBS-O) (2a) and (dppe)Pt(MBS-NH) (2b) have been synthesized and structurally characterized. Experimental results show that compound 2b is an efficient initiator toward ring opening polymerization of NCA yielding polypeptides with narrow PDls (1.07-1.19).By comparing the activity of complexes 2a with that of 2b, the mechanism for polymerization of NCA initiated by an amido-sulfonamidate is proposed.
關聯:	第五屆海峽化學、生物及材料研討會，起迄日：2008/07/21-2008/07/22，地點：嘉南藥理科技大學
Appears in Collections:	[藥理學院] 2008第五屆海峽化學、生物及材料研討會

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