Preparation of Polypeptide via Living Polymerization of Z-Lys-NCA Initiated by Platinum Complexes

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Title:	Preparation of Polypeptide via Living Polymerization of Z-Lys-NCA Initiated by Platinum Complexes
Authors:	Ya-Liu Peng Shu-Ling Lai Chu-Chieh Lin
Contributors:	Department of Chemistry, National Chung Hsing University College of Design, Ling Tung University
Date:	2008-07
Issue Date:	2017-12-04 15:53:59 (UTC+8)
Abstract:	Two novel platinum complexes, ((dppe)Pt(MBS-O) (2a) and (dppe)Pt(MBS-NH) (2b) have been synthesized and structurally characterized. Experimental results show that compound 2b is an efficient initiator toward ring opening polymerization of NCA yielding polypeptides with narrow PDls (1.07-1.19).By comparing the activity of complexes 2a with that of 2b, the mechanism for polymerization of NCA initiated by an amido-sulfonamidate is proposed.
Relation:	第五屆海峽化學、生物及材料研討會，起迄日：2008/07/21-2008/07/22，地點：嘉南藥理科技大學
Appears in Collections:	[Pharmacy and Science] The 5rh Conference of Channel-bridge Chemistry, Biology and materal Science

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