本計畫目標係針對東協市場需求提供優質平價保養品而進行之產品開發與設計，故本計劃擬以高品質中價位之抗皺保養品為研發標的，利用次微米結構載體包覆技術，開發具有競爭力之新穎抗皺保養品。 由於抗皺及美白成分較不安定，為了防止不受空氣中的自由基所攻擊進而氧化，因此選擇使用次微米結構載體來進行包覆。比之微脂體更可降低成本，較符合東協市場平價的需求。 本計畫成功開發次微米結構載體(NLCs)包覆蝦紅素，本實驗以葡萄糖苷界面活性劑製備NLCs，經三個月儲存粒徑小於300nm，蝦紅素包埋率>90%，蝦紅素降解率不超過10%。皮膚過敏性測試結果過敏人數小於5%為低過敏性，在經皮吸收實驗結果顯示，使用NLCs載體皮膚吸收率比傳統乳液與精華液相較來的好。 The objective of this project is to develop the effective skin cares for ASEAN Market。In this project, the nanostructured lipid carriers(NLC) encapsulated effective ingredient was allpied to the skin cares for anti-wrinkling product. The ingredients for anti-wrinkling are usually unstable, the encapsulation of active compound into NLC can improve the stability. The cost is lower in comparison with liposome. This project successfully develop the NLCs encapsulated with astaxanthin. The particle size is less then 300 nm and the degradation is less then 10% after three months storage. The skin irritation test result showed less then 5%. The skin absorption of astaxanthin in NLCs is better then in lotion.
